Mouse Anti-FUT4 Recombinant Antibody (VS-0924-YC25) - Cancer Stem Cell Marker (CAT#: VS-0924-YC25)
This product is an antibody panel comprising anti-FUT4 recombinant antibody (VS-0924-YC43) and anti-FUT4 recombinant antibody (VS-0924-YC44). These antibodies specifically target the human FUT4 protein, which is a marker for cancer stem cells (CSCs). The monoclonal antibodies (mAbs) are suitable for detecting FUT4 in CSC tissues or cells through western blot analysis at a concentration of 1 µg/mL.
| Sub Cat | Type | Concentration | |
| VS-0924-YC43 | Mouse IgG2a | 1.0 mg/mL | |
| VS-0924-YC44 | Mouse IgG2b | 0.2 mg/mL |
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/204_F1_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/204_F1_2_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/301_B_6_4_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/301_B_6_4_selected.jpg
Figure 3 Kidney
(Distal tubules Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_A_7_5.jpg
(Distal tubules Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_A_7_5.jpg
Figure 4 High expression in bone marrow.
(Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_B_4_4.jpg
(Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_B_4_4.jpg
Figure 5 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196371-FUT4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196371-FUT4
Specifications
- Host Species
- Mouse
- Specificity
- Human FUT4
- Species Reactivity
- Human
- Applications
- WB
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.2, with 40% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (WB): 1 µg/mL
Target
- Alternative Names
- Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; Alpha (1,3) Fucosyltransferase, Myeloid-Specific; ELAM-1 Ligand Fucosyltransferase; ELAM Ligand Fucosyltransferase; Fucosyltransferase IV; FUC-TIV; FucT-IV; FCT3A; ELFT; Stage-Specific Embryonic Antigen 1
- Gene ID
- 2526
- UniProt ID
- P22083
- Long Name
- Fucosyltransferase 4
- Sequence Similarities
- Belongs to the glycosyltransferase 10 family.
- Cellular Localization
- Golgi apparatus, Membrane
- Protein Refseq
- NP_002024.1
- Function
- Isoform Short:
Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:29593094, PubMed:1702034, PubMed:1716630).
Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:29593094, PubMed:1716630).
Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity).
In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:1716630, PubMed:11278338).
Isoform Long:
Does not generate Lewis X antigens.
Recommended Products
Isotype Control
Secondary Antibody
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-706 | Anti-FUT4/CD15 Recombinant Antibody (Fanolesomab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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