Mouse Anti-FUT4 Recombinant Antibody (VS-0924-YC25) - Cancer Stem Cell Marker
CAT#: VS-0924-YC25
This product is an antibody panel comprising anti-FUT4 recombinant antibody (VS-0924-YC43) and anti-FUT4 recombinant antibody (VS-0924-YC44). These antibodies specifically target the human FUT4 protein, which is a marker for cancer stem cells (CSCs). The monoclonal antibodies (mAbs) are suitable for detecting FUT4 in CSC tissues or cells through western blot analysis at a concentration of 1 µg/mL.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/204_F1_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14/301_B_6_4_selected.jpg
Normal Tissue
Figure 3 Kidney
Distal tubules Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_A_7_5.jpg
Normal Tissue
Figure 4 High expression in bone marrow.
Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16129/161283_B_4_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196371-FUT4
❮
❯
| Sub Cat | Type | Concentration | |
| VS-0924-YC43 | Mouse IgG2a | 1.0 mg/mL | |
| VS-0924-YC44 | Mouse IgG2b | 0.2 mg/mL |
Specifications
- Host Species
- Mouse
- Specificity
- Human FUT4
- Species Reactivity
- Human
- Applications
- WB
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.2, with 40% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (WB): 1 µg/mL
Target
- Alternative Names
- Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; Alpha (1,3) Fucosyltransferase, Myeloid-Specific; ELAM-1 Ligand Fucosyltransferase; ELAM Ligand Fucosyltransferase; Fucosyltransferase IV; FUC-TIV; FucT-IV; FCT3A; ELFT; Stage-Specific Embryonic Antigen 1
- Gene ID
- 2526
- UniProt ID
- P22083
- Long Name
- Fucosyltransferase 4
- Sequence Similarities
- Belongs to the glycosyltransferase 10 family.
- Cellular Localization
- Golgi apparatus, Membrane
- Protein Refseq
- NP_002024.1
- Function
- Isoform Short:
Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:29593094, PubMed:1702034, PubMed:1716630).
Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:29593094, PubMed:1716630).
Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity).
In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:1716630, PubMed:11278338).
Isoform Long:
Does not generate Lewis X antigens.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| FN-030CQ | Mouse Anti-FUT4 Recombinant Antibody (FN-030CQ) | FC, FuncS, IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
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| HPAB-0995WJ-S(P) | Human Anti-FUT4 Recombinant Antibody (clone 3-17); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY736 | Mouse Anti-FUT4 Recombinant Antibody, FITC (clone 4AHI98) | FC, IHC, ICC, IF, IP | Mouse IgM |
| VS3-XY737 | Mouse Anti-FUT4 Recombinant Antibody, FITC (clone 4AW6D3A12) | FC, IF | Mouse IgG1 |
| VS3-XY738 | Mouse Anti-FUT4 Recombinant Antibody, PE (clone 4AHI98) | FC, IHC, ICC, IF, IP | Mouse IgM |
| VS3-XY739 | Mouse Anti-FUT4 Recombinant Antibody (clone 4AHI98) | FC, IHC, ICC, IF, IP | Mouse IgM |
| VS3-XY740 | Mouse Anti-FUT4 Recombinant Antibody (clone 4AW6D3A12) | FC, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC96 | Recombinant Anti-FUT4 Vesicular Antibody, EV Displayed (VS-0425-YC96) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY2676 | Anti-Mouse FUT4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2677 | Anti-Monkey FUT4 Immunohistochemistry Kit | IHC |
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