Ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin has been focused on as a target molecule for passive immunotherapy. Provided is a mouse antibody, KM641, specific for human ganglioside (GD3). KM641 has the potential to be a useful agent for passive immunotherapy of human cancer.
Figure 1 Enzyme-linked immunosorbent assay analysis of chimeric KM871.
Comparison of the reactivity with GD3 between chimeric KM871 and murine KM641.
Figure 2 Flow-cytometric analysis of the cell binding of chimeric KM871 and murine KM641.
Neuroblastoma P122 cells and melanoma G361 cells were reacted with murine anti- (salmon growth hormone) mAb, KM737 (control antibody), murine KM641 and chimeric KM871. The cells were then stained with fluorescein-isothiocyanate-labeled protein Aand analyzed by flow cytometry.
Figure 3 Antitumor effects of chimeric KM871 and murine KM641 on transplanted tumor in nude mice.
Each point represents the mean and SD from five to seven animals. Murine KM231, anti-sialyl-Le a mAb, was used as a negative control antibody.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABW-049 | Human Anti-GD3 Recombinant Antibody (clone chR24) | ELISA | Chimeric (mouse/human) IgG |
PABC-050 | Mouse Anti-GD3 Recombinant Antibody (clone R24) | ELISA | Mouse IgG |
FAMAB-0128YC | Human Anti-GD3 Recombinant Antibody (clone KM871) | ELISA, FC, Cyt | Chimeric (mouse/human) IgG1, κ |
HPAB-0001LY | Mouse Anti-GD3 Recombinant Antibody (clone 19B) | IHC, TLC immunostaining | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-049 | Human Anti-GD3 Recombinant Antibody (clone chR24); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
PFBC-050 | Mouse Anti-GD3 Recombinant Antibody (clone R24); Fab Fragment | ELISA | Mouse Fab |
FAMAB-0127-YC-F(E) | Mouse Anti-GD3 Recombinant Antibody (clone KM641); Fab Fragment | ELISA, FC, Cyt | Mouse Fab |
FAMAB-0128-YC-F(E) | Human Anti-GD3 Recombinant Antibody (clone KM871); Fab Fragment | ELISA, FC, Cyt | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-049 | Mouse Anti-GD3 Recombinant Antibody (clone chR24); scFv Fragment | ELISA | Mouse scFv |
PSBC-050 | Mouse Anti-GD3 Recombinant Antibody (clone R24); scFv Fragment | ELISA | Mouse scFv |
FAMAB-0127-YC-S(P) | Mouse Anti-GD3 Recombinant Antibody (clone KM641); scFv Fragment | ELISA, FC, Cyt | Mouse scFv |
FAMAB-0128-YC-S(P) | Mouse Anti-GD3 Recombinant Antibody (clone KM871); scFv Fragment | ELISA, FC, Cyt | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-079CQ | Human Anti-GD3 Recombinant Antibody (TAB-079CQ) | ELISA | Human IgM |
TAB-079CQ-S(P) | Human Anti-GD3 Recombinant Antibody; scFv Fragment (TAB-079CQ-S(P)) | ELISA | Human scFv |
TAB-080CQ-S(P) | Human Anti-GD3 Recombinant Antibody; scFv Fragment (TAB-080CQ-S(P)) | ELISA | Human scFv |
TAB-079CQ-F(E) | Human Anti-GD3 Recombinant Antibody; Fab Fragment (TAB-079CQ-F(E)) | ELISA | Human Fab |
TAB-080CQ-F(E) | Human Anti-GD3 Recombinant Antibody; Fab Fragment (TAB-080CQ-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-081CQ | Human Anti-GD3 Recombinant Antibody (TAB-081CQ) | Inhib, ELISA, WB, FC | Humanized antibody |
TAB-081CQ-S(P) | Human Anti-GD3 Recombinant Antibody; scFv Fragment (TAB-081CQ-S(P)) | IF, ELISA | Humanized scFv |
TAB-081CQ-F(E) | Human Anti-GD3 Recombinant Antibody; Fab Fragment (TAB-081CQ-F(E)) | IF, ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-082CQ | Human Anti-GD3 Recombinant Antibody (TAB-082CQ) | IF, ELISA | Chimeric antibody (mouse/human) |
TAB-082CQ-S(P) | Mouse Anti-GD3 Recombinant Antibody; scFv Fragment (TAB-082CQ-S(P)) | IF, ELISA | Mouse scFv |
TAB-082CQ-F(E) | Human Anti-GD3 Recombinant Antibody; Fab Fragment (TAB-082CQ-F(E)) | IF, ELISA | Chimeric antibody (mouse/human) |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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