Anti-GFAP (clone W24V101) Recombinant Antibody Coupled Liposome (VS-1024-FY103)
CAT#: VS-1024-FY103
Liposomal delivery systems conjugated with anti-GFAP antibodies are considered promising in the treatment of gliomas. These liposomes can serve as effective drug delivery vehicles, directly transporting anticancer drugs to the central nervous system, thereby enhancing the therapeutic efficacy against glioblastoma (GBM). Related research suggests that this approach may provide new insights for clinical treatment.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56030/1475_F11_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56030/1326_A1_4_blue_red_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56030/135460_B_9_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000131095-GFAP
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V101
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that selectively interacts with human glial fibrillary acidic protein (GFAP). GFAP is an intermediate filament protein predominantly expressed in astrocytes, a type of glial cell in the central nervous system. The binding specificity of this antibody enables it to effectively target and identify GFAP in various biological samples.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- GFAP
- Introduction
- This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Alternative Names
- Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD
- Full Name
- Glial Fibrillary Acidic Protein
- Gene ID
- 2670
- UniProt ID
- P14136
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Cytoplasm, Intermediate filament
- Post Translation Modifications
- Phosphorylated by PKN1.
- Protein Refseq
- NP_001124491.1; NP_001229305.1; NP_002046.1
- Function
- GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0805MZ | Chicken Anti-GFAP Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| BRD-1122MZ | Chicken Anti-GFAP Polyclonal IgY | IHC, IF, WB | Chicken antibody |
| BRD-1174MZ | Chicken Anti-Glial Fibrillary Acidic Protein (GFAP) Polyclonal IgY | WB, ICC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1426 | Hi-Affi™ Rabbit Anti-GFAP Recombinant Antibody (clone DS1426AB) | ICC, IHC-Fr, IHC-P, IP, WB | Rabbit IgG |
| MOR-0100-FY | Rabbit Anti-GFAP Recombinant Antibody (clone AFY0071) | ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0197-WJ-S(P) | Mouse Anti-GFAP Recombinant Antibody (clone 5C8); scFv Fragment | ELISA, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0197-WJ-F(E) | Mouse Anti-GFAP Recombinant Antibody (clone 5C8); Fab Fragment | ELISA, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS4-WK195 | Mouse Anti-GFAP Recombinant Antibody (VS4-WK195) | ELISA, WB | Mouse IgG |
| VS3-WK1842 | Recombinant Rabbit Anti-GFAP Capture Antibody (clone R94-7L-3) | ELISA | Rabbit IgG |
| VS3-WK1843 | Recombinant Rabbit Anti-GFAP Detection Antibody (clone R85-2U-2) | ELISA | Rabbit IgG |
| VS3-WK1844 | Recombinant Rabbit Anti-Mouse GFAP Capture Antibody (clone R36-2N-1) | ELISA | Rabbit IgG |
| VS3-WK1845 | Recombinant Rabbit Anti-Mouse GFAP Detection Antibody (clone R81-7S-4) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC176 | AbPlus™ Anti-GFAP Magnetic Beads (VS-0724-YC176) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY912 | Anti-GFAP Immunohistochemistry Kit | IHC | |
| VS-0525-XY2784 | Anti-Mouse GFAP Immunohistochemistry Kit | IHC | |
| VS-0525-XY2783 | Anti-Human GFAP Immunohistochemistry Kit | IHC | |
| VS-0525-XY2785 | Anti-Porcine GFAP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC444 | CytoStream™ Mouse Anti-GFAP Recombinant Antibody (VS13-YC444) | WB, IHC-P, ICC, IF, FC | Mouse IgG1 |
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