Human Anti-GM3 Recombinant Antibody (clone L612) (CAT#: FAMAB-0055WJ)
This product is a human IgM antibody recognizes melanoma-associated ganglioside GM3.
Specific Inquiry
FC
Figure 1 Fluorescence-activated cell sorting analysis of the binding of L612, CA19, CJ45, and LA74 to GM3-positive or GM2-positive cancer cell lines.
GM3-positive mouse B16F10 melanoma cells (A), GM3-positive humanM1 melanoma cells (B), and GM3-negative but GM2-positive human A549 lung cancer cells (C) were incubated with100 Ag/mL CA19, CJ45, L612, LA74, control human IgM (Cont. IgM), or no antibody (No1st Ab) and analyzed as described in Materials and Methods.
Azuma, Y., Ishikawa, Y., Kawai, S., Tsunenari, T., Tsunoda, H., Igawa, T., ... & Tsuchiya, M. (2007). Recombinant human hexamer-dominant IgM monoclonal antibody to ganglioside GM3 for treatment of melanoma. Clinical cancer research, 13(9), 2745-2750.
Cyt
Figure 2 CDC from L612, CA19, and CJ45 against GM3-positive or GM3-negative culture cells.
Antibody-inducedCDC against B16F10 mouse melanoma cells, M1human melanoma cells, and A549 human lung cancer cells was tested using human serum complement.
Azuma, Y., Ishikawa, Y., Kawai, S., Tsunenari, T., Tsunoda, H., Igawa, T., ... & Tsuchiya, M. (2007). Recombinant human hexamer-dominant IgM monoclonal antibody to ganglioside GM3 for treatment of melanoma. Clinical cancer research, 13(9), 2745-2750.
Specifications
- Host Species
- Human
- Type
- Human IgM
- Specificity
- Human GM3
- Species Reactivity
- Human
- Clone
- L612
- Applications
- WB, FC, Cyt
- Related Disease
- Melanoma
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The GM3 antibody has been reported in applications of Western Blot, Flow Cytometry, Cytotoxicity.
Target
- Alternative Names
- Ganglioside GM3; GM3; monosialodihexosylganglioside
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Fragment Antibody
scFv Fragment Antibody
Recombinant Antibody
Human Antibody
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-407-F(E) | Recombinant Anti-GM3 Antibody Fab Fragment | IF, FuncS | Fab |
| MHH-407-F(E) | Recombinant Human Anti-GM3 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| PFBC-051 | Mouse Anti-GM3 Recombinant Antibody (clone 14F7); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0190CQ-F(E) | Recombinant Human Anti-GM3 Antibody Fab Fragment (L612) | ELISA | Human Fab |
| FAMAB-0055WJ-F(E) | Human Anti-GM3 Recombinant Antibody (clone L612); Fab Fragment | WB | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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