Rabbit Anti-GPR37 Recombinant Antibody (clone R02-9I6)
CAT#: VS3-FY1731
This anti-GPR37 antibody plays a role in western blot analysis of GPCR GPR37 in rat brain lysates. It is a rabbit recombinant monoclonal antibody with a high affinity of human and rat GPR37. The immunogen of this antibody is a synthetic peptide of human GPCR GPR37.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to nuclear membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42903/1593_A6_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68009/153072_B_9_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68009/153072_A_8_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, fHDF/TERT166, hTCEpi, SK-BR-3, SuSa, TIME)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000170775-GPR37
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WB
Figure 1 Anti-GPR37 Antibody (VS3-FY1731) in WB.
The GPCR GPR37 expression in rat Brain lysates were detected using the anti-GPR37 by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human GPCR GPR37
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat GPR37
- Species Reactivity
- Human, Rat
- Clone
- R02-9I6
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 67 kDa, while the observed molecular weight stands at 67 kDa.
- Related Disease
- Juvenile Parkinson disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- G Protein-Coupled Receptor 37; G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like); Parkin-Associated Endothelin Receptor-Like Receptor; Endothelin B Receptor-Like Protein 1; ETBR-LP-1; PAELR; Probable G-Protein Coupled Receptor 37
- Gene ID
- 2861
- UniProt ID
- O15354
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, Synapse
- Post Translation Modifications
- The N-terminus is cleaved by ADAM10 metalloproteinase; mediating limited proteolysis leading to the release of receptor ectodomain by shedding (PubMed:26869225, PubMed:34042202).
In addition, cleaved by FURIN between Arg-54 and Asp-55 (PubMed:34042202).
Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.
- Protein Refseq
- NP_005293.1
- Function
- Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.
Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway. Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GPR37"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1495 | Rabbit Anti-GPR37 Recombinant Antibody (clone DS1495AB) | WB | Rabbit IgG |
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