Anti-GPX3 (clone W24V102) Recombinant Antibody Coupled Liposome (VS-1024-FY104)
CAT#: VS-1024-FY104
The application of anti-GPX3 antibody-conjugated liposomes in glioma may be related to improving therapeutic efficacy and targeted drug delivery. GPX3 is an extracellular glutathione peroxidase that exhibits elevated expression levels in certain cancers, which is associated with tumor progression and modulation of cell death. By utilizing anti-GPX3 antibody-conjugated liposomes, drugs or therapeutic agents can be effectively delivered directly to GPX3-expressing tumor cells, thereby enhancing the specificity and effectiveness of the treatment.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69456/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69456/150676_B_7_5.jpg
Normal Tissue
Figure 3 Small intestine
Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69456/150676_A_4_2.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69456/150676_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69456/150676_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69456/150676_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000211445-GPX3
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V102
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that exhibits a high specificity for human glutathione peroxidase 3 (GPX3). GPX3 is an important enzyme that plays a critical role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides, thereby contributing to cellular antioxidant defense mechanisms.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- GPX3
- Introduction
- Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione
- Alternative Names
- GPX3; GPXP; GSHPx-3; Extracellular Glutathione Peroxidase; Plasma Glutathione Peroxidase; EC 1.11.1; EC 1.11.1.9; GPx-P; GPx-3; Glutathione Peroxidase 3 (Plasma); Glutathione Peroxidase 3; GSHPx-P
- Full Name
- Glutathione Peroxidase 3
- Gene ID
- 2878
- UniProt ID
- P22352
- Sequence Similarities
- Belongs to the glutathione peroxidase family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- The N-terminus is blocked. ( P22352-GPX3_HUMAN )
Modification sites at PhosphoSitePlus ( P22352 )
Modification sites at neXtProt
- Protein Refseq
- NP_001316719.1; NP_002075.2
- Function
- Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
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Datasheet
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COA
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See other products for "GPX3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2587z | Mouse Anti-GPX3 Recombinant Antibody (clone 24G9) | WB, ELISA, IP | Mouse IgG2b |
| MOB-0761MZ | Recombinant Mouse Anti-Human GPX3 Antibody (clone 66B) | ELISA | Mouse antibody |
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