Llama Anti-GRM1 Recombinant Antibody (clone Nb43) (CAT#: VS-0624-FY10)
This product is a Lama glama anti-human mGlu1 recombinant Single Domain Antibody known as Nb43. It exhibits an affinity for both monomers present in the dimeric mGlu1. The interaction of Nb43 with the full-length dimeric mGlu1 results in the adoption of the "Aco" conformation.
Specific Inquiry
Subcellular Location
Normal Tissue
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/if_selected.jpg
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/ihc_selected.jpg
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/ihc_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_B_7_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_B_7_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_9_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_9_3.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_8_5.jpg
Figure 6 Testis
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_6_6.jpg
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_6_6.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15701/35557_A_9_8.jpg
Specifications
- Host Species
- Llama
- Type
- Lama VHH
- Specificity
- Human GRM1
- Species Reactivity
- Human
- Clone
- Nb43
- Applications
- Immunoassay
- Related Disease
- Spinocerebellar Ataxia, Autosomal Recessive 13 and Spinocerebellar Ataxia 44
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Ni-NTA Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- GRM1; GPRC1A; MGLU1; MGLUR1; PPP1R85; SCAR13; glutamate metabotropic receptor 1; SCA44
- Gene ID
- 2911
- UniProt ID
- Q13255
- Long Name
- GRM1
- Sequence Similarities
- G-protein coupled receptor 3 family
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn98, Asn223, Asn397, and Asn515 (NX_Q13255 [NX_Q13255-1])
Modification sites at PhosphoSitePlus (Q13255)
Glycosylation from GlyGen
- Protein Refseq
- XP_011534084.1; XP_016866272.1; XP_016866273.1; XP_016866277.1; XP_054211223.1
- Function
- G-protein coupled receptor for glutamate.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
Signaling activates a phosphatidylinositol-calcium second messenger system.
May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, 28886343, 7476890).
May function in the light response in the retina (By similarity).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2579z | Mouse Anti-GRM1 Recombinant Antibody (clone 28G5) | ELISA, WB | Mouse IgG1 |
| MRO-0993-CN | Rabbit Anti-GRM1 Recombinant Antibody (clone JM11-61) | WB, IHC | Rabbit IgG |
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