Anti-GRN (clone W24V146) Recombinant Antibody Coupled Liposome (VS-1024-FY146)
CAT#: VS-1024-FY146
The application of anti-GRN antibody-conjugated liposomes in colorectal cancer aims to enhance drug efficacy by specifically targeting the GRN protein, thereby inhibiting tumor cell proliferation. Research indicates that such liposomes can increase the accumulation and delivery of drugs within tumor tissues, providing a more precise therapeutic approach.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to lysosomes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8763/100_A3_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to endosomes & lysosomes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/548_F4_2_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19394/618_F6_3_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_9_8.jpg
Normal Tissue
Figure 7 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19394/43509_B_7_5.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_8_3.jpg
Normal Tissue
Figure 9 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_9_4.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000030582-GRN
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More Infomation
Specifications
- Potential Clinical Applications
- Colorectal cancer
Product Composition
- Clone
- W24V146
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a specially engineered human monoclonal antibody that has been developed to selectively target Granulin (GRN). By focusing on GRN, this antibody aims to modulate its activity and address various pathological conditions associated with its dysregulation. The recombinant nature of this antibody ensures high specificity and efficacy in binding to GRN, potentially leading to improved therapeutic outcomes. Researchers are optimistic that the use of this targeted approach could pave the way for new treatments in diseases linked to GRN abnormalities.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- GRN
- Introduction
- Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling
- Alternative Names
- GRN; PEPI; CLN11; Granulin; Proepithelin; PCDGF; Granulins; Granulin-Epithelin; GP88; PC Cell-Derived Growth Factor; Acrogranin; PGRN; GEP; Progranulin
- Full Name
- Granulin Precursor
- Gene ID
- 2896
- UniProt ID
- P28799
- Sequence Similarities
- Belongs to the granulin family.
- Cellular Localization
- Secreted, Lysosome
- Post Translation Modifications
- Cleaved by ELANE; proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production; granulin-3 and granulin-4 are resistant to ELANE (PubMed:12526812, 28743268).
Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome (PubMed:28743268).
Glycosylation at Asn265, Asn118, Thr182, Asn368, Asn236, Asn530, and Thr532 (NX_P28799 [NX_P28799-1])
Modification sites at PhosphoSitePlus (P28799)
Glycosylation from GlyConnect GRN_HUMAN (1290)
Glycosylation from GlyGen (P28799) 9 sites, 5 N-linked glycans (1 site), 5 O-linked glycans (3 sites)
- Protein Refseq
- NP_002078.1
- Function
- In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity).
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Datasheet
MSDS
COA
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See other products for "GRN"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2578z | Mouse Anti-GRN Recombinant Antibody (clone 5B10) | WB, IHC | Mouse IgG1 |
| MOB-1403MZ | Recombinant Mouse Anti-Human GRN Antibody (clone 1F5) | ICC, IF, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1521 | Rabbit Anti-GRN Recombinant Antibody (clone DS1521AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| MOR-1522 | Rabbit Anti-Grn Recombinant Antibody (clone DS1522AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY954 | Anti-GRN Immunohistochemistry Kit | IHC | |
| VS-0525-XY2938 | Anti-Mouse Grn Immunohistochemistry Kit | IHC | |
| VS-0525-XY2937 | Anti-Human GRN Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC474 | CytoStream™ Rabbit Anti-GRN Recombinant Antibody (VS13-YC474) | WB, IHC-P, ICC, IF, IP, FC | Rabbit IgG |
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