Specifications

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Gasdermin D of human

Species Reactivity
Human

Applications
WB

Conjugate
Unconjugated, FITC

Related Disease
Cinca Syndrome and Familial Cold Autoinflammatory Syndrome

Product Property

Clonality
Monoclonal Antibody

Format
Liquid

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Gasdermin D; Gasdermin Domain-Containing Protein 1; Gasdermin Domain Containing 1; GSDMDC1; DFNA5L; Gasdermin-D; FKSG10; DF5L

Gene ID
79792

UniProt ID
P57764

Sequence Similarities
Belongs to the gasdermin family.

Cellular Localization
Nucleus

Post Translation Modifications
Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms), CASP4, CASP5 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis.
Cleavage by CASP1 and CASP4 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part.
Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (By similarity).
Cleavage at Asp-87 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis, but generates the Gasdermin-D, p13 chain, which translocates to the nucleus and acts as a transcription regulator.
Cleavage by papain allergen generates the Gasdermin-D, p40 chain

Protein Refseq
NP_001159709.1; NP_079012.3

Function
Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. Promotes pyroptosis in response to microbial infection and danger signals.

Recommended Products

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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IgG Antibody Products

CAT	Product Name	Application	Type
MOB-0037CT	Recombinant Mouse anti-Human GSDMD Monoclonal antibody (EML1922)	IHC-P, WB

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