Camelid Anti-GSN Recombinant Single Domain Antibody (NBD-0041-YJ-VHH) (CAT#: NBD-0041-YJ-VHH)
This product is a recombinant Llama single domain antibody that recognizes Human GSN. The sdAb's protective effect is based on the enhancement of the thermodynamic stability of different G2 mutants (D187N, G167R and N184K).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16728/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16728/if_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in dendritic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54026/138110_A_5_8_selected.jpg
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in dendritic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54026/138110_A_5_8_selected.jpg
Figure 3 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_8.jpg
Figure 4 Cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_B_7_5.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_B_7_5.jpg
Figure 5 Lung
(Alveolar cells type I Staining: Low Intensity: Weak Quantity: 75%-25% Alveolar cells type I I Staining: Low Intensity: Weak Quantity: 75%-25% Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Macrophages Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_2_4.jpg
(Alveolar cells type I Staining: Low Intensity: Weak Quantity: 75%-25% Alveolar cells type I I Staining: Low Intensity: Weak Quantity: 75%-25% Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Macrophages Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_2_4.jpg
Figure 6 Colon
(Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_3.jpg
(Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_3.jpg
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, HaCaT)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148180-GSN
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148180-GSN
Specifications
- Immunogen
- Human recombinant gelsolin.
- Host Species
- Camelid
- Type
- Camelid VHH
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- NBD-0041-YJ-VHH
- Applications
- ELISA, IF, Inhib
- Related Disease
- AGel amyloidosis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This sdAb has been reported for use in Enzyme-linked Immunosorbent Assay, Immunofluorescence, Inhibition.
Target
- Alternative Names
- ADF; AGEL; actin-depolymerizing factor; brevin; epididymis secretory sperm binding protein
- Gene ID
- 2934
- UniProt ID
- P06396
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgM Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2035z | Mouse Anti-GSN Recombinant Antibody (clone 33A5) | WB, ELISA, ICC, IF, IHC | Mouse IgG1, κ |
| MOB-2046MZ | Recombinant Mouse Anti-Human GSN Antibody (clone HFM-53) | FC, IHC-Fr, IHC-P, WB | Mouse antibody |
| MRO-0645-CN | Rabbit Anti-GSN Recombinant Antibody (clone JB36-68) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY625 | Recombinant Rabbit Anti-GSN Antibody (clone R06-4B4) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| VS3-FY1726 | Rabbit Anti-GSN Recombinant Antibody (clone R06-2I7) | WB, IHC-P, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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