Camelid Anti-GSN Recombinant Single Domain Antibody (NBD-0041-YJ-VHH) (CAT#: NBD-0041-YJ-VHH)
This product is a recombinant Llama single domain antibody that recognizes Human GSN. The sdAb's protective effect is based on the enhancement of the thermodynamic stability of different G2 mutants (D187N, G167R and N184K).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16728/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16728/if_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in dendritic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54026/138110_A_5_8_selected.jpg
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in dendritic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54026/138110_A_5_8_selected.jpg
Figure 3 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_8.jpg
Figure 4 Cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_B_7_5.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_B_7_5.jpg
Figure 5 Lung
(Alveolar cells type I Staining: Low Intensity: Weak Quantity: 75%-25% Alveolar cells type I I Staining: Low Intensity: Weak Quantity: 75%-25% Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Macrophages Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_2_4.jpg
(Alveolar cells type I Staining: Low Intensity: Weak Quantity: 75%-25% Alveolar cells type I I Staining: Low Intensity: Weak Quantity: 75%-25% Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Macrophages Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_2_4.jpg
Figure 6 Colon
(Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_3.jpg
(Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_3.jpg
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, HaCaT)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148180-GSN
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148180-GSN
Specifications
- Immunogen
- Human recombinant gelsolin.
- Host Species
- Camelid
- Type
- Camelid VHH
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- NBD-0041-YJ-VHH
- Applications
- ELISA, IF, Inhib
- Related Disease
- AGel amyloidosis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This sdAb has been reported for use in Enzyme-linked Immunosorbent Assay, Immunofluorescence, Inhibition.
Target
- Alternative Names
- ADF; AGEL; actin-depolymerizing factor; brevin; epididymis secretory sperm binding protein
- Gene ID
- 2934
- UniProt ID
- P06396
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2035z | Mouse Anti-GSN Recombinant Antibody (clone 33A5) | WB, ELISA, ICC, IF, IHC | Mouse IgG1, κ |
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| MRO-0645-CN | Rabbit Anti-GSN Recombinant Antibody (clone JB36-68) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY625 | Recombinant Rabbit Anti-GSN Antibody (clone R06-4B4) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| VS3-FY1726 | Rabbit Anti-GSN Recombinant Antibody (clone R06-2I7) | WB, IHC-P, IP | Rabbit IgG |
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