Recombinant Human Anti-HA Antibody (F026-427) (CAT#: FAMAB-0150YC)

F045-092 was extensively analyzed. It neutralized not only H3N2 but also H1N1, H2N2 and H5N1 viruses, although the activities were largely varied. Flow cytometry suggested that it have the ability to bind to HA and HA1 artificially expressed on the cell surface. It is likely that F045-092 bind to a conserved epitope in the head region formed by HA1. Interestingly, while the VH1-69 gene can encode mAbs against the HA stem that are group 1 specific, F045-092 and its relatives that recognize the head region also use VH1-69.

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WB

Figure 1 F045-092 and F026-427 binding to virus strains.

Figure 1 F045-092 and F026-427 binding to virus strains.

Western blot of three H3 strain viruses and one H1 strain virus with Fab-cp3 of four clones under nonreducing conditions.

ELISA

Figure 2 Binding activities of IgG from F045-092 (gray) and F026-427 (white) to 12 H3 viruses and 1 H1 virus were measured by ELISA.

Figure 2 Binding activities of IgG from F045-092 (gray) and F026-427 (white) to 12 H3 viruses and 1 H1 virus were measured by ELISA.

The OD values at 492 nm are indicated.

FC

Figure 3 FCM analyses of the cells expressing HA and HA1 of Aichi/68 virus.

Figure 3 FCM analyses of the cells expressing HA and HA1 of Aichi/68 virus.

FCM signals for mock transfection (gray-filled area), HA-expressing cells (green), and HA1-expressing cells (pink) are shown.


Specifications

  • Host Species
  • Human
  • Derivation
  • Phage display library
  • Type
  • Human IgG
  • Specificity
  • H3N2 HA
  • Species Reactivity
  • H3N2, H1N1, H2N2, H5N1
  • Clone
  • F026-427
  • Applications
  • Flow Cytometry, Neutralization
  • Related Disease
  • Influenza

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • HA; Hemagglutinin; HA1; HA2

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Humanized Antibody

CAT Product Name Application Type
PABX-070-S (P) Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) WB, ELISA, Neut, FuncS scFv

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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