Mouse Anti-HACE1 Recombinant Antibody (VS3-FY2730) (CAT#: VS3-FY2730)
The anti-HACE1 product is a recombinant mouse monoclonal antibody that binds to HACE1 protein, a calculated weight of 102.3 kDa. It cross-reacts with human, mouse and rat. This monoclonal antibody is potential for conducting research on Spastic Paraplegia and Psychomotor Retardation with or without Seizures and Charcot-Marie-Tooth Disease, Axonal, Type 2W. This monoclonal antibody can be used in Western Blot.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_selected.jpg
Figure 2 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1609_E5_1_red_green.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1609_E5_1_red_green.jpg
Figure 3 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_red_green.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_red_green.jpg
Figure 4 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085382-HACE1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085382-HACE1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 102.3 kDa.
- Related Disease
- Spastic Paraplegia And Psychomotor Retardation With Or Without Seizures and Charcot-Marie-Tooth Disease, Axonal, Type 2W
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Target
- Alternative Names
- HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1; HECT-Type E3 Ubiquitin Transferase HACE1; HECT Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1; E3 Ubiquitin-Protein Ligase HACE1; EC 2.3.2.26; KIAA1320; EC 6.3.2; SPPRS
- Gene ID
- 57531
- UniProt ID
- Q8IYU2
- Cellular Localization
- Golgi apparatus, Golgi stack membrane
Cytoplasm
Endoplasmic reticulum
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_001308009.1; NP_001308012.1; NP_001308013.1; NP_001337483.1; NP_001337484.1
- Function
- Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.
Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens.
May also act as a transcription regulator via its interaction with RARB.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HACE1"
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IgG Antibodies
Rabbit Monoclonal Antibodies
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-343 | Human Anti-HACE1 Recombinant Antibody (clone D420) | ELISA, IP-MS | Human IgG |
| VS3-WK1056 | Mouse Anti-HACE1 Recombinant Antibody (VS3-WK1056) | WB | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
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