Mouse Anti-HACE1 Recombinant Antibody (VS3-FY2730) (CAT#: VS3-FY2730)
The anti-HACE1 product is a recombinant mouse monoclonal antibody that binds to HACE1 protein, a calculated weight of 102.3 kDa. It cross-reacts with human, mouse and rat. This monoclonal antibody is potential for conducting research on Spastic Paraplegia and Psychomotor Retardation with or without Seizures and Charcot-Marie-Tooth Disease, Axonal, Type 2W. This monoclonal antibody can be used in Western Blot.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_selected.jpg
Figure 2 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1609_E5_1_red_green.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1609_E5_1_red_green.jpg
Figure 3 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_red_green.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46071/1634_E5_1_red_green.jpg
Figure 4 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085382-HACE1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085382-HACE1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 102.3 kDa.
- Related Disease
- Spastic Paraplegia And Psychomotor Retardation With Or Without Seizures and Charcot-Marie-Tooth Disease, Axonal, Type 2W
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Target
- Alternative Names
- HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1; HECT-Type E3 Ubiquitin Transferase HACE1; HECT Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1; E3 Ubiquitin-Protein Ligase HACE1; EC 2.3.2.26; KIAA1320; EC 6.3.2; SPPRS
- Gene ID
- 57531
- UniProt ID
- Q8IYU2
- Cellular Localization
- Golgi apparatus, Golgi stack membrane
Cytoplasm
Endoplasmic reticulum
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_001308009.1; NP_001308012.1; NP_001308013.1; NP_001337483.1; NP_001337484.1
- Function
- Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.
Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens.
May also act as a transcription regulator via its interaction with RARB.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-343 | Human Anti-HACE1 Recombinant Antibody (clone D420) | ELISA, IP-MS | Human IgG |
| VS3-WK1056 | Mouse Anti-HACE1 Recombinant Antibody (VS3-WK1056) | WB | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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