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    Human Anti-HARS Recombinant Antibody (clone KL31-240) (CAT#: HPAB-N0350-YC)

    Provided are antibodies that specifically bind to human histidyl-tRNA synthetase. The antibody can be used for treating cancer, including as standalone therapies or in combination with cancer immunotherapies, for example, immune checkpoint modulators such as PD-1 inhibitors.

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    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human skin
    Figure 1 IHC staining of human skin
    (Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/ihc_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_B_8_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_9_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_8_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_5_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_9_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000170445-HARS

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG4, κ
    • Specificity
    • Human HARS
    • Species Reactivity
    • Human, Cynomolgus
    • Clone
    • KL31-240
    • Applications
    • ELISA, FC

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE and HPLC analysis
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • Histidyl-TRNA Synthetase; EC 6.1.1.21; HisRS; HRS; Histidine TRNA Ligase 1, Cytoplasmic; Histidine--TRNA Ligase, Cytoplasmic

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "Clone KL31-240"

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    CAT Product Name Application Type
    MOB-2392z Mouse Anti-HARS Recombinant Antibody (clone 40C3) WB, FC, ICC, IP, Dot Mouse IgG1
    MOB-2302MZ Recombinant Mouse Anti-Human HARS Antibody WB Mouse antibody
    FAMAB-0005JF Chicken Anti-HARS Recombinant Antibody (clone 4B1) IB, WB, ELISA, FuncS
    ZG-445C Human Anti-HARS Recombinant Antibody (ZG-445C) ELISA Human IgG1, κ
    VS3-QX498 Mouse Anti-HARS Recombinant Antibody (clone 4H5-D9-D4) WB Mouse IgG1

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