Human Anti-HARS Recombinant Antibody (clone KL31-478) (CAT#: HPAB-N0349-YC)
Provided are antibodies that specifically bind to human histidyl-tRNA synthetase. The antibody can be used for treating cancer, including as standalone therapies or in combination with cancer immunotherapies, for example, immune checkpoint modulators such as PD-1 inhibitors.
Specific Inquiry
FC
Figure 1 show that anti-HRS antibodies from the KL31 series blocked binding of Fc-HRS(2-60) to NRP2 in a concentration-dependent manner, whereas other antibodies of the AB04 and AB13 series did not demonstrate significant blocking characteristics in this assay.
Fig.A shows control human IgG1 (filled circles), KL31-467 (filled triangles), KL31-356 (partially filled triangles), mouse clone 13C8 (crosses), and Fig.B shows control human IgG1 (filled circles), AB04-425 (open triangles), AB13-288 (partially filled squares), and KL31-478 (filled triangles), which are shown as the percentage of streptavidinPE+/NRP2+ cells in the viable singlet gate.
Specifications
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- Human HARS
- Species Reactivity
- Human, Cynomolgus
- Clone
- KL31-478
- Applications
- ELISA, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry. Please see the Published Data for further information.
Target
- Alternative Names
- Histidyl-TRNA Synthetase; EC 6.1.1.21; HisRS; HRS; Histidine TRNA Ligase 1, Cytoplasmic; Histidine--TRNA Ligase, Cytoplasmic
- Gene ID
- 3035
- UniProt ID
- P12081
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone KL31-478"
See other products for "HARS"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2392z | Mouse Anti-HARS Recombinant Antibody (clone 40C3) | WB, FC, ICC, IP, Dot | Mouse IgG1 |
| MOB-2302MZ | Recombinant Mouse Anti-Human HARS Antibody | WB | Mouse antibody |
| FAMAB-0005JF | Chicken Anti-HARS Recombinant Antibody (clone 4B1) | IB, WB, ELISA, FuncS | |
| ZG-445C | Human Anti-HARS Recombinant Antibody (ZG-445C) | ELISA | Human IgG1, κ |
| VS3-QX498 | Mouse Anti-HARS Recombinant Antibody (clone 4H5-D9-D4) | WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1564 | Rabbit Anti-HARS Recombinant Antibody (clone DS1564AB) | WB, IHC-P, IP | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0349-YC-S(P) | Human Anti-HARS Recombinant Antibody (clone KL31-478); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-N0350-YC-S(P) | Human Anti-HARS Recombinant Antibody (clone KL31-240); scFv Fragment | ELISA, FC | Human scFv |
| FAMAB-0005JF-S(P) | Chicken Anti-HARS Recombinant Antibody (clone 4B1); scFv Fragment | IB, WB, ELISA, FuncS | Chicken scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0349-YC-F(E) | Human Anti-HARS Recombinant Antibody (clone KL31-478); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-N0350-YC-F(E) | Human Anti-HARS Recombinant Antibody (clone KL31-240); Fab Fragment | ELISA, FC | Human Fab |
| FAMAB-0005JF-F(E) | Chicken Anti-HARS Recombinant Antibody (clone 4B1); Fab Fragment | IB, WB, ELISA, FuncS | Chicken Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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