Mouse Anti-HARS Recombinant Antibody (VS3-FY2731)
CAT#: VS3-FY2731
The anti-HARS antibody is a mouse recombinant monoclonal antibody that is designed to selectively bind to human HARS protein. It exhibits cross-reactivity with mouse, monkey. This monoclonal antibody is potential for conducting research on disease research of Charcot-Marie-Tooth Disease, Axonal, Type 2W and Usher Syndrome, Type Iiib. Its utility extends to application: Western Blot assay.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human skin
Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_5_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36539/75988_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000170445-HARS
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Histidyl-TRNA Synthetase of human, mouse and monkey origins
- Species Reactivity
- Human, Mouse, Monkey
- Applications
- WB
- Conjugate
- Unconjugated, FITC
- Related Disease
- Charcot-Marie-Tooth Disease, Axonal, Type 2W and Usher Syndrome, Type Iiib
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Histidyl-TRNA Synthetase; EC 6.1.1.21; HisRS; HRS; Histidine TRNA Ligase 1, Cytoplasmic; Histidine--TRNA Ligase, Cytoplasmic
- Gene ID
- 3035
- UniProt ID
- P12081
- Sequence Similarities
- Belongs to the class-II aminoacyl-tRNA synthetase family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys75 and Lys230
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001244969.1; NP_001244970.1; NP_001244971.1; NP_001276021.1; NP_001276022.1
- Function
- Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198).
Plays a role in axon guidance.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "HARS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2392z | Mouse Anti-HARS Recombinant Antibody (clone 40C3) | WB, FC, ICC, IP, Dot | Mouse IgG1 |
| HPAB-N0349-YC | Human Anti-HARS Recombinant Antibody (clone KL31-478) | ELISA, FC | Human IgG1, κ |
| HPAB-N0350-YC | Human Anti-HARS Recombinant Antibody (clone KL31-240) | ELISA, FC | Human IgG4, κ |
| ZG-445C | Human Anti-HARS Recombinant Antibody (ZG-445C) | ELISA | Human IgG1, κ |
| VS3-QX498 | Mouse Anti-HARS Recombinant Antibody (clone 4H5-D9-D4) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1564 | Rabbit Anti-HARS Recombinant Antibody (clone DS1564AB) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0349-YC-S(P) | Human Anti-HARS Recombinant Antibody (clone KL31-478); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-N0350-YC-S(P) | Human Anti-HARS Recombinant Antibody (clone KL31-240); scFv Fragment | ELISA, FC | Human scFv |
| FAMAB-0005JF-S(P) | Chicken Anti-HARS Recombinant Antibody (clone 4B1); scFv Fragment | IB, WB, ELISA, FuncS | Chicken scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0349-YC-F(E) | Human Anti-HARS Recombinant Antibody (clone KL31-478); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-N0350-YC-F(E) | Human Anti-HARS Recombinant Antibody (clone KL31-240); Fab Fragment | ELISA, FC | Human Fab |
| FAMAB-0005JF-F(E) | Chicken Anti-HARS Recombinant Antibody (clone 4B1); Fab Fragment | IB, WB, ELISA, FuncS | Chicken Fab |
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