Human Anti-HBV preS Recombinant Antibody (clone ZP39) (CAT#: FAMAB-0220JF)
Recombinant monoclonal antibody specially binds to HBV preS2. The neutralizing activity of this human anti-HBV preS2 antibody (ZP39) was approximately 1000 times higher than commercially available polyclonal hepatitis B immune globulin. This production is useful in the prevention of HBY infection.
Specific Inquiry
ELISA
Figure 1 Scanning of the preS portion of HBV env protein for regions optimally recognized by anti-HBV env protein antibodies and eticiting the highest levels of antibodies reacting with HBV env proteins.
Peptides defined on the abscissa were synthesized and used to raise anti-peptide antisera.
Neurath, A. R., Kent, S. B., Parker, K., Prince, A. M., Strick, N., Brotman, B., & Sproul, P. (1986). Antibodies to a synthetic peptide from the preS 120–145 region of the hepatitis B virus envelope are virus-neutralizing. Vaccine, 4(1), 35-37.
Inhib
Figure 2 Relationship between MA18/7 inhibiting anti-preS1 reactivity and anti-HBs titers in naturally immune persons.
All results are representative of at least four independent experiments.
Deepen, R., Heermann, K. H., Uy, A., Thomssen, R., & Gerlich, W. H. (1990). Assay of preS epitopes and preS1 antibody in hepatitis B virus carriers and immune persons. Medical microbiology and immunology, 179(1), 49-60.
Specifications
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- HBV preS2
- Species Reactivity
- HBV
- Clone
- ZP39
- Applications
- Inhib, ELISA
- Related Disease
- HBV
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HBV preS antibody has been reported in applications of Inhibition, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Hepatitis B virus; HBV; preS; HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S; Hepatitis B Surface Antigen; Hepatitis B Virus Surface Antigen; Hepadnaviridae; Orthohepadnavirus
- Function
- Neutralizing HBV
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-641CQ | Recombinant Mouse Anti-HBV preS Antibody (1898) | ELISA, IF, WB | Mouse antibody |
| MRO-649CQ | Recombinant Mouse Anti-HBV preS Antibody (S26) | ELISA, IF, WB | Mouse antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0220JF-F(E) | Human Anti-HBV preS Recombinant Antibody (clone ZP39); Fab Fragment | WB, ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0220JF-S(P) | Human Anti-HBV preS Recombinant Antibody (clone ZP39); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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