This is a human IgG3-lambda antibody specially binds to domain I of glycoprotein B (gB) of human cytomegalovirus (HCMV). Clone 1G2 has a reactivity with domain I peptide (aa 132-344) and has a 50% neutralization at concentrations of 0.2-1.3 mg/ml.
Figure 1 EM two-dimensional class averages of gB-698glyco (top panels) and gB-698glyco in complex with 1G2 Fab.
Each value represents the mean ± S.E.M. of duplicate measurements from at least four independent experiments.
Chandramouli, S., Ciferri, C., Nikitin, P. A., Caló, S., Gerrein, R., Balabanis, K., ... & Carfi, A. (2015). Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nature communications, 6(1), 1-12.
Figure 2 FACS analysis of BHK cells electroporated with RNA encoding full-length gB and stained with monoclonal antibodies 1G2 and ITC88 24 h post electroporation.
The gB staining histograms were gated on viable, dsRNA+ cells.
Chandramouli, S., Ciferri, C., Nikitin, P. A., Caló, S., Gerrein, R., Balabanis, K., ... & Carfi, A. (2015). Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nature communications, 6(1), 1-12.
Figure 3 Western blot analysis of purified VR1814 virions immunoprecipitated with 1G2 or ITC88.
Samples were resolved on SDS–polyacrylamide gel electrophoresis and detected with ITC88 mAb.
Chandramouli, S., Ciferri, C., Nikitin, P. A., Caló, S., Gerrein, R., Balabanis, K., ... & Carfi, A. (2015). Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nature communications, 6(1), 1-12.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-443 | Recombinant Anti-HCMV GB Antibody | ELISA, WB, IP, FuncS | IgG |
FAMAB-0173CQ | Recombinant Mouse Anti-HCMV gB Antibody (7-17) | ELISA, Neut | Mouse IgG3, κ |
FAMAB-0144JF | Human Anti-HCMV gB Recombinant Antibody (clone 2C2) | WB, Neut, IHC | Human IgG1, κ |
FAMAB-0145JF | Human Anti-HCMV gB Recombinant Antibody (clone SM1-6) | WB, ELISA, FuncS | Human IgG1, λ |
FAMAB-1777CQ | Human Anti-HCMV GB Recombinant Antibody (clone 5A6) | IP, Neut, FC, IF | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-443-F(E) | Recombinant Anti-HCMV GB Antibody Fab Fragment | WB, IF, FuncS | Fab |
FAMAB-0173CQ-F(E) | Recombinant Mouse Anti-HCMV gB Antibody Fab Fragment (7-17) | ELISA, Neut | Mouse Fab |
HPAB-0639-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2F10) | ELISA, Neut | Human Fab |
HPAB-0640-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2M16) | ELISA, Neut | Human Fab |
HPAB-0641-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2N9) | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1032LC | Anti-HCMV gB Recombinant Antibody (TI-23) | ELISA | Humanized antibody |
MRO-1032LC-S(P) | Anti-HCMV gB Recombinant Antibody scFv Fragment (TI-23) | ELISA | Humanized antibody |
MRO-1032LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (TI-23) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1033LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C1) | ELISA | Human antibody |
MRO-1034LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C3) | ELISA | Human antibody |
MRO-1035LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C4) | ELISA | Human antibody |
MRO-1036LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C7) | ELISA | Human antibody |
MRO-1037LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C23) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-1438LC | Recombinant Human Anti-HCMV gB Antibody (MAb C23) | WB | IgG1 |
EPAF-1497LC | Recombinant Mouse Anti-HCMV gB Antibody (CH28-2) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0639-CN-S(P) | Recombinant Human Anti-HCMV gB Antibody scFv Fragment (2F10) | ELISA, Neut | Human scFv |
HPAB-0640-CN-S(P) | Recombinant Human Anti-HCMV gB Antibody scFv Fragment (2M16) | ELISA, Neut | Human scFv |
HPAB-0641-CN-S(P) | Recombinant Human Anti-HCMV gB Antibody scFv Fragment (2N9) | ELISA, Neut | Human scFv |
HPAB-0642-CN-S(P) | Recombinant Human Anti-HCMV gB Antibody scFv Fragment (4P12) | ELISA, Neut | Human scFv |
FAMAB-0142JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone SM10); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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