Human Anti-HCMV gB Recombinant Antibody (clone 2C2) (CAT#: FAMAB-0144JF)
Recombinant monoclonal antibody binds to domain I of glycoprotein B (gB) of human cytomegalovirus (HCMV). This human anti-gB antibody (2C2) could be useful as biologicals in prophylaxis of HCMV infections.
Specific Inquiry
WB
Figure 1 Specificity of the serologic response of mice immunized with either vaccinia virus- or E. coli-derived HCMV.
The Mr was determined by comparison of migration with known molecular weight standards.
Britt, W. J., Vugler, L., & Stephens, E. B. (1988). Induction of complement-dependent and-independent neutralizing antibodies by recombinant-derived human cytomegalovirus gp55-116 (gB). Journal of virology, 62(9), 3309-3318.
Neut
Figure 2 Boosting of the neutralizing antibody response in mice immunized with recombinant HCMV.
Animals initially immunized with E. coli-derived HCMV were bled 60 days following the primary immunization and boosted with live recombinant HCMV vaccinia virus as described.
Britt, W. J., Vugler, L., & Stephens, E. B. (1988). Induction of complement-dependent and-independent neutralizing antibodies by recombinant-derived human cytomegalovirus gp55-116 (gB). Journal of virology, 62(9), 3309-3318.
IHC
Figure 3 Expression of HCMV gB on the surface of HCMV gB-VAC recombinant virus infected cells.
Monoclonal antibody 39 was reacted with CV-1 cells infected either with HCMV gB-VAC.
Cranage, M. P., Kouzarides, T., Bankier, A. T., Satchwell, S., Weston, K., Tomlinson, P., ... & Minson, A. C. (1986). Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus. The EMBO journal, 5(11), 3057-3063.
Specifications
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- HCMV gB
- Species Reactivity
- HCMV
- Clone
- 2C2
- Applications
- WB, Neut, IHC
- Related Disease
- HCMV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HCMV gB antibody has been reported in applications of Western Blot, Neutralization, Immunohistochemistry.
Target
- Alternative Names
- Human Cytomegalovirus; HCMV; Human Cytomegalovirus envelope glycoprotein B; HCMV gB
- Gene ID
- 3077424
- UniProt ID
- F5HB53
- Function
- Neutralization
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 2C2"
See other products for "HCMV GB"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-443 | Recombinant Anti-HCMV GB Antibody | ELISA, WB, IP, FuncS | IgG |
| FAMAB-0173CQ | Recombinant Mouse Anti-HCMV gB Antibody (7-17) | ELISA, Neut | Mouse IgG3, κ |
| FAMAB-0145JF | Human Anti-HCMV gB Recombinant Antibody (clone SM1-6) | WB, ELISA, FuncS | Human IgG1, λ |
| FAMAB-1777CQ | Human Anti-HCMV GB Recombinant Antibody (clone 5A6) | IP, Neut, FC, IF | Human IgG1 |
| FAMAB-0582WJ | Human Anti-HCMV gB Recombinant Antibody (clone h272.7) | ELISA, WB, Neut | Human IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1032LC | Anti-HCMV gB Recombinant Antibody (TI-23) | ELISA | Humanized antibody |
| MRO-1032LC-S(P) | Anti-HCMV gB Recombinant Antibody scFv Fragment (TI-23) | ELISA | Humanized antibody |
| MRO-1032LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (TI-23) | ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1033LC-S(P) | Anti-HCMV gB Recombinant Antibody scFv Fragment (C1) | ELISA | Human antibody |
| MRO-1033LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C1) | ELISA | Human antibody |
| MRO-1034LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C3) | ELISA | Human antibody |
| MRO-1035LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C4) | ELISA | Human antibody |
| MRO-1036LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C7) | ELISA | Human antibody |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1438LC | Recombinant Human Anti-HCMV gB Antibody (MAb C23) | WB | IgG1 |
| EPAF-1497LC | Recombinant Mouse Anti-HCMV gB Antibody (CH28-2) | ELISA |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0173CQ-S(P) | Recombinant Mouse Anti-HCMV gB Antibody scFv Fragment (7-17) | ELISA, Neut | Mouse scFv |
| FAMAB-0142JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone SM10); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0143JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone 1G2); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0144JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone 2C2); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0145JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone SM1-6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0639-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2F10) | ELISA, Neut | Human Fab |
| HPAB-0640-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2M16) | ELISA, Neut | Human Fab |
| HPAB-0641-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2N9) | ELISA, Neut | Human Fab |
| HPAB-0642-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (4P12) | ELISA, Neut | Human Fab |
| HPAB-0643-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (5P9) | ELISA, Neut | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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