AbPlus™ Anti-HDAC4 Magnetic Beads (VS-0724-YC1024)
CAT#: VS-0724-YC1024
The AbPlus Anti-HDAC4 Magnetic Beads (VS-0724-YC1024) is an innovative affinity resin which is bound with anti-HDAC4 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of HDAC4 protein under native and denaturing conditions.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to nucleoplasm, nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48723/1855_B7_15_cr5ad8881abe486_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71448/168654_A_9_2_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48723/736_E10_1_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71448/168654_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71448/168654_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71448/168654_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71448/168654_A_6_6.jpg
Normal Tissue
Figure 8 Skeletal muscle
Myocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71448/168654_B_2_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71448/168654_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000068024-HDAC4
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-HDAC4 specific antibody
- Target
- HDAC4
- Immunogen
- Synthetic peptide corresponding to the N-terminus of the human HDAC4.
- Target Species
- Human, Mouse, Rat
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
- Alternative Names
- Histone Deacetylase 4; EC 3.5.1.98; HD4; Brachydactyly-Mental Retardation Syndrome; Histone Deacetylase A; KIAA0288; HA6116;
- Gene ID
- 9759
- UniProt ID
- P56524
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "HDAC4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-344 | Human Anti-HDAC4 Recombinant Antibody (clone D430) | ELISA, IP-MS | Human IgG |
| ZG-0415J | Mouse Anti-HDAC4 Recombinant Antibody (ZG-0415J) | WB, ELISA | Mouse IgG |
| ZG-0416J | Mouse Anti-HDAC4 Recombinant Antibody (ZG-0416J) | WB | Mouse IgG |
| ZG-0417J | Mouse Anti-HDAC4 Recombinant Antibody (ZG-0417J) | WB | Mouse IgG |
| VS3-QX506 | Mouse Anti-HDAC4 Recombinant Antibody (clone 4A3-H7-C6) | WB, IP | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1576 | Rabbit Anti-HDAC4 Recombinant Antibody (clone DS1576AB) | ICC, IF, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1002 | Anti-HDAC4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3098 | Anti-Human HDAC4 Immunohistochemistry Kit | IHC |
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