Mouse Anti-HIST1H2BB Recombinant Antibody (VS3-FY2735)
CAT#: VS3-FY2735
The anti-HIST1H2BB antibody is a mouse IgG recombinant monoclonal antibody. It has been specifically designed to target the human Histone H2B protein. It cross-reacts with mouse and rat. The monoclonal antibody is suitable for use in Western Blot, Immunohistochemistry assays.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42205/113823_B_8_5.jpg
Normal Tissue
Figure 2 Testis
Elongated or late spermatids Staining: Not detected Intensity: Weak Quantity: <25% Leydig cells Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: Low Intensity: Weak Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42205/113823_A_6_6.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42205/113823_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (K-562, Karpas-707, MOLT-4, NB-4, THP-1, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000276410-HIST1H2BB
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Histone cluster 1 H2B family member B of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC
- Conjugate
- Unconjugated, FITC
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Histone Cluster 1 H2B Family Member B; H2B Histone Family, Member F; Histone Cluster 1, H2bb; Histone 1, H2bb; Histone H2B.1; Histone H2B.F
- Gene ID
- 3018
- UniProt ID
- P33778
- Sequence Similarities
- Belongs to the histone H2B family.
- Cellular Localization
- Nucleus
Chromosome
- Post Translation Modifications
- Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
Glycosylation at Ser113
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 2 O-linked glycans (2 sites)
- Protein Refseq
- NP_066406.1
- Function
- Core component of nucleosome.
Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "HIST1H2BB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1605 | Rabbit Anti-HIST1H2BB Recombinant Antibody (clone DS1605AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0103C | Mouse Anti-HIST1H2BB Antibody (clone Mix) | WB, IF, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC784 | AbPlus™ Anti-HIST1H2BB Magnetic Beads (VS-0724-YC784) | IP, Protein Purification |
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