This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to HIV-1. Itolizumab (INN, trade name Alzumab) is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. Itolizumab, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation. A double blind, placebo controlled, phase III treat –Plaq study of itolizumab successfully met the pre-specified primary end-point of significant improvement in PASI-75 (Psoriasis Area and Severity Index) score after 12 weeks of treatment in patients with moderate to severe psoriasis compared to placebo. Biocon has received marketing authorization for the drug from the Drugs Controller General of India (DCGI).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Anti-HIV-1 Recombinant Antibody (Suvizumab)Recombinant monoclonal antibody to HIV-1. Itolizumab (INN, trade name Alzumab) is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. Itolizumab, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation. A double blind, placebo controlled, phase III treat –Plaq study of itolizumab successfully met the pre-specified primary end-point of significant improvement in PASI-75 (Psoriasis Area and Severity Index) score after 12 weeks of treatment in patients with moderate to severe psoriasis compared to placebo. Biocon has received marketing authorization for the drug from the Drugs Controller General of India (DCGI).
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1889-sdAb | Recombinant Anti-HIV-1 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
PNBL-038 | Recombinant Anti-HIV-1 C186 gp120 VHH Single Domain Antibody (A12) | WB, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-068 | Anti-HIV-1 Recombinant Antibody (Suvizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
PABX-094-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (Fab4025) | WB, ELISA, FuncS | scFv |
PABX-099-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment | FC, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G037E | Anti-HIV-1 immunotoxin 3B3 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G037D | Anti-HIV-1 immunotoxin 3B3 (scFv)-DT | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25) | WB, ELISA, Neut, FuncS | Human IgG1 |
FAMAB-0176CQ | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10) | ELISA, Neut | Mouse IgG |
VS-0423-XY8 | Mouse Anti-HIV-1 Recombinant Antibody (clone CP503) | ELISA | Mouse IgG |
VS-0423-XY9 | Mouse Anti-HIV-1 Recombinant Antibody (clone CP506) | ELISA | Mouse IgG |
VS-0423-XY10 | Mouse Anti-HIV-1 Recombinant Antibody (clone CP507) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
FAMAB-0176CQ-F(E) | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10); Fab Fragment | ELISA, Neut | Mouse Fab |
HPAB-0158-YJ-F(E) | Human Anti-HIV-1 Recombinant Antibody; Fab Fragment (HPAB-0158-YJ-F(E)) | ELISA, Neut, Inhib | Human Fab |
HPAB-1988-FY-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone 2G9); Fab Fragment | FC, ELISA | Human Fab |
HPAB-1989-FY-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone 9F11); Fab Fragment | FC, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-001 | Recombinant Human Anti-HIV-1 Antibody (1281) | WB, FuncS, Neut, SPR | IgG |
PABX-008-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment | WB, IHC, IF, FuncS | scFv |
PABX-095-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab59.1) | Neut, ELISA, FuncS | scFv |
PABX-001-F (E) | Recombinant Human Anti-HIV-1 Antibody Fab Fragment (1281) | WB, FuncS | Fab |
PABX-087-F(E) | Human Anti-HIV-1 Recombinant Antibody; Fab Fragment (PABX-087-F(E)) | WB, ELISA, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-001-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (1281) | WB, FuncS | scFv |
PABX-084-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (83.1) | WB, ELISA, FuncS | Fab |
PABX-089-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (A10F9) | Neut, FuncS | Fab |
PABX-093-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (Fab28) | WB, ELISA, FuncS | Fab |
PABX-095-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (Fab59.1) | Neut, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-093-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab28) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1376 | PE-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1377 | APC-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1378 | BV421-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4221 | Rabbit Anti-HIV-1 Recombinant Antibody (clone SI300DS) | ELISA, ICC, IF, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0176CQ-S(P) | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10); scFv Fragment | ELISA, Neut | Mouse scFv |
HPAB-0158-YJ-S(P) | Mouse Anti-HIV-1 Recombinant Antibody; scFv Fragment (HPAB-0158-YJ-S(P)) | ELISA, Neut, Inhib | Mouse scFv |
HPAB-AP363-YC-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone A2); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1988-FY-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone 2G9); scFv Fragment | FC, ELISA | Human scFv |
HPAB-1989-FY-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone 9F11); scFv Fragment | FC, ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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