Human Anti-HIV-1 gp120 Recombinant Antibody (clone CC3C2) (CAT#: MRO-3120CQ)
Recombinant human antibody to gp120. CC3C2, had low to no ADCC activity against gp120 from any clade, including subtype B ADCC targets.
Specific Inquiry
ELISA
Figure 1 Reactivities of 13 hMAbs against a panel of five autologous gp120 proteins included in the DP6-001 trial measured by ELISA.
HIV-1 Env gp120 proteins were derived from the following isolates: 92UG037.8 (A2), 92US715.6 (B), Ba-L (Bal), 96ZM651 (Czm), and 93TH976.17 (AE).
Costa, M. R., Pollara, J., Edwards, R. W., Seaman, M. S., Gorny, M. K., Montefiori, D. C., ... & Wang, S. (2016). Fc receptor-mediated activities of Env-specific human monoclonal antibodies generated from volunteers receiving the DNA prime-protein boost HIV vaccine DP6-001. Journal of virology, 90(22), 10362-10378.
FuncS
Figure 2 ADCC reactivities of 13 hMAbs with a panel of DP6-001 gp120 proteins.
HIV-1 Env gp120 proteins were derived from the following isolates: 92UG037.8 (A2), 92US715.6 (B), Ba-L (Bal), 96ZM651 (Czm), and 93TH976.17 (AE).
Costa, M. R., Pollara, J., Edwards, R. W., Seaman, M. S., Gorny, M. K., Montefiori, D. C., ... & Wang, S. (2016). Fc receptor-mediated activities of Env-specific human monoclonal antibodies generated from volunteers receiving the DNA prime-protein boost HIV vaccine DP6-001. Journal of virology, 90(22), 10362-10378.
Specifications
- Host Species
- Human
- Type
- Human IgG1, λ
- Specificity
- Recognizes HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- CC3C2
- Applications
- ELISA, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay and Function Assay.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 58.2) | Neut | Mouse IgG1 |
| PABC-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 83.1) | Neut | Mouse IgG1 |
| PABZ-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 0.5β) | Neut | Mouse IgG |
| PABC-062 | Recombinant Human Anti-HIV-1 gp120 Antibody (2G12) | Neut, ELISA | IgG |
| PABC-063 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 47e) | Neut | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-538 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3B3); Fab Fragment | Neut | Human Fab |
| PFBL-540 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 537-10D); Fab Fragment | ELISA | Human Fab |
| PFBL-541 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b13); Fab Fragment | Neut | Human Fab |
| PFBL-543 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247); Fab Fragment | Neut | Humanized Fab |
| PFBL-546 | Human Anti-HIV-1 gp120 V1V2 domain Recombinant Antibody (clone P4); Fab Fragment | WB, IF, FuncS | Human Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
| MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
| MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
| MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
| MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
| MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
| MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
| MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
| MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-132LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT123) | ELISA, WB, IF, Neut | Mouse antibody |
| MRO-133LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT267) | ELISA, WB, Neut | Mouse antibody |
| MRO-134LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT085) | ELISA, WB, IF, Neut | Mouse antibody |
| MRO-150LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-4) | ELISA, Inhib, FC, Neut, RIPA, DB, IP | Mouse antibody |
| MRO-152LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-136) | Neut, ELISA | Mouse antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
| MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
| MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3465CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 5E8); scFv Fragment | ELISA, FC | Human scFv |
| MRO-3466CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 9F7); scFv Fragment | ELISA, FC | Human scFv |
| MRO-3467CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 43D7); scFv Fragment | ELISA, FC | Human scFv |
| MRO-3468CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 7B9N); scFv Fragment | ELISA, FC | Human scFv |
| MRO-3469CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 4E3); scFv Fragment | ELISA, FC | Human scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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