Recombinant human antibody to gp120. 2C6 showed significant binding only to the Gag-Env pseudovirions and not to the gp120 monomer. 2C6 showed low-level neutralization activity against HIV BaL which increased with the addition of sCD4.
Figure 1 MAb 2C6 binding recapitulates B cell clonal supernatant screening ELISA results.
Binding specificity of mAb 2C6 and control mAb RV6-26 expressed as Fabs against the following HIV antigens were assayed by ELISA: BaL gp120 monomer, Gag VLPs, and Gag-Env-VLPs (parental strain of Env was BaL).
Hicar, M. D., Chen, X., Briney, B., Hammonds, J., Wang, J. J., Kalams, S., ... & Crowe Jr, J. E. (2010). Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV. Journal of acquired immune deficiency syndromes (1999), 54(3), 223.
Figure 2 Neutralization of Fab 2C6 compared to known CD4i mAb 17b.
HIV strain BaL was incubated for 90 min at room temperature with Abs (12.5 µg/ml) in theabsence or presence of 0.075 µg/ml of soluble CD4. Neutralization was detected 48 hours later. HIV immune patient serum was used as a positive control.
Hicar, M. D., Chen, X., Briney, B., Hammonds, J., Wang, J. J., Kalams, S., ... & Crowe Jr, J. E. (2010). Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV. Journal of acquired immune deficiency syndromes (1999), 54(3), 223.
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CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-028LC-VHH) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-029LC-VHH) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-030LC-VHH) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-031LC-VHH) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-543 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247); Fab Fragment | Neut | Humanized Fab |
PFBL-546 | Human Anti-HIV-1 gp120 V1V2 domain Recombinant Antibody (clone P4); Fab Fragment | WB, IF, FuncS | Human Fab |
PFBL-547 | Human Anti-HIV-1 gp120 V1V2 domain Recombinant Antibody (clone PG10); Fab Fragment | WB, IF, FuncS | Human Fab |
PFBL-548 | Human Anti-HIV-1 gp120 V1V2 region Recombinant Antibody (clone 830A); Fab Fragment | WB, IF, FuncS | Human Fab |
PSBZ-209 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L3); scFv Fragment | Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC | Anti-HIV-1 gp120 Recombinant Antibody (D59/A2) | ELISA | Mouse antibody |
MRO-042LC | Anti-HIV-1 gp120 Recombinant Antibody (F58/H3) | WB, ELISA | Mouse antibody |
MRO-043LC | Anti-HIV-1 gp120 Recombinant Antibody (P1/D12) | ELISA | Mouse antibody |
MRO-044LC | Anti-HIV-1 gp120 Recombinant Antibody (P4/D10) | ELISA | Mouse antibody |
MRO-045LC | Anti-HIV-1 gp120 Recombinant Antibody (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-155LC | Anti-HIV-1 gp120 Recombinant Antibody (GP44) | ELISA | Human antibody |
MRO-156LC | Anti-HIV-1 gp120 Recombinant Antibody (GP68) | ELISA, Inhib | Human antibody |
MRO-157LC | Anti-HIV-1 gp120 Recombinant Antibody (MN215) | ELISA | Human antibody |
MRO-161LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-161LC) | ELISA | Human IgG1, κ |
MRO-162LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-162LC) | ELISA, FC, Neut, SPR | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-4366CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (1E2 (VHH 1E2)) | Neut | Camelid VHH |
MRO-4367CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (1F10 (VHH 1F10)) | Neut | Camelid VHH |
MRO-4368CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (2D4 (VHH 2D4)) | Neut | Camelid VHH |
MRO-4369CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (2E7 (VHH 2E7)) | Neut | Camelid VHH |
MRO-4370CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (C8 (VHH C8)) | Neut | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3371CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone m14); scFv Fragment | Neut | Human scFv |
MRO-3373CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CC6C11); scFv Fragment | ELISA, FC | Human scFv |
MRO-3374CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CC6B5); scFv Fragment | ELISA, FC | Human scFv |
MRO-3635CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone MAG 95); scFv Fragment | ELISA, RIA | Mouse scFv |
MRO-3636CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone MAG 97); scFv Fragment | ELISA, RIA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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