Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2.1E (2.1e)) (CAT#: MRO-3663CQ)
Recombinant human antibody to gp120 V3. 2.1E was able to bind subtype B V3 in the subtype C Env backbone chimera, but not the reverse, indicating that 2.1E binds to a structure created by the subtype B V3 sequence that is not impacted by the gp120 backbone.
Specific Inquiry
ELISA
Figure 1 Binding of V3 MAbs to gp120 monomers and V3 peptides.
The titration curves represent the binding of gp120 from viral lysates of CC1/85 cl.7 (squares), CC1/85 cl.6 (diamonds), CC101.19 cl.7 (triangles) and D1/85.16 cl.23 (circles) to Mab 2.1e.
Berro, R., Sanders, R. W., Lu, M., Klasse, P. J., & Moore, J. P. (2009). Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry. PLOS Pathogens, 5(8).
Inhib
Figure 2 Sensitivity of parental and VVC-resistant clones to V3 MAbs.
Chimeric molecular clones CC1/85 cl.7 (squares), CC1/85 cl.6 (diamonds), CC101.19 cl.7 (triangles) and D1/85.16 cl.23 (circles) were used to infect PBMCs in the presence of the indicated concentrations of MAb 2.1e.
Berro, R., Sanders, R. W., Lu, M., Klasse, P. J., & Moore, J. P. (2009). Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry. PLOS Pathogens, 5(8).
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Recognizes HIV-1 gp120 V3
- Species Reactivity
- HIV-1
- Clone
- 2.1E (2.1e)
- Applications
- ELISA, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120 V3 loop; gp120 V3 loop; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 2.1E (2.1e)"
See other products for "HIV-1 gp120 V3"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-477-S(P) | Recombinant Anti-HIV-1 gp120 V3 Antibody scFv Fragment | WB, FC, FuncS | scFv |
| MHH-477-S(P) | Recombinant Human Anti-HIV-1 gp120 V3 Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| PSBL-176 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2424); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBC-067 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody; scFv Fragment (PSBC-067) | ELISA, Neut | Human scFv |
| MRO-3663CQ-S(P) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2.1E (2.1e)); scFv Fragment | ELISA | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-176 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2424) | WB, ELISA, FuncS | Human IgG1, κ |
| MRO-1821CQ | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 39F) | Neut | Human IgG1 |
| MRO-1822CQ | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone F425-B4a1) | Neut, FC | Human IgG1, λ |
| MRO-3664CQ | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 3904) | ELISA, Neut | Human IgG1, κ |
| MRO-3665CQ | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 4121) | ELISA, Neut | Human IgG1, λ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-176 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2424); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| MRO-3663CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2.1E (2.1e)); Fab Fragment | ELISA | Human Fab |
| MRO-3664CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 3904); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-3665CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 4121); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-3666CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 3694); Fab Fragment | ELISA, Neut | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-068LC | Anti-HIV-1 gp120 V3 Recombinant Antibody (HGN194) | ELISA, Neut | Human antibody |
| MRO-068LC-S(P) | Anti-HIV-1 gp120 V3 Recombinant Antibody scFv Fragment (HGN194) | ELISA | Human antibody |
| MRO-068LC-F(E) | Anti-HIV-1 gp120 V3 Recombinant Antibody Fab Fragment (HGN194) | ELISA | Human antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for MRO-3663CQ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.