Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone SAR1) (CAT#: MRO-3960CQ)
Recombinant mouse antibody to gp160(738-744). This ERDRD-specific MAb recognizes an externalized loop of the gp41 C-terminal domain, and can reduce the yield of infectious progeny and inhibit fusion post-attachment, but not neutralize free virus.
Specific Inquiry
Inhib
Figure 1 SAR1 inhibited fusion of HIV-1-infected cells with noninfected cells.
C8166 cells were infected and incubated for 3 days at 37 C.
Heap, C. J., Reading, S. A., & Dimmock, N. J. (2005). An antibody specific for the C-terminal tail of the gp41 transmembrane protein of human immunodeficiency virus type 1 mediates post-attachment neutralization, probably through inhibition of virus–cell fusion. Journal of general virology, 86(5), 1499-1507.
FC
Figure 2 FACS analysis of intact Env-expressing cells demonstrates extracellular exposure of the KE sequence.
Intact cells expressing Env were stained for surface exposure of the KE using a native KE antibody, SAR1.
Steckbeck, J. D., Sun, C., Sturgeon, T. J., & Montelaro, R. C. (2010). Topology of the C-terminal tail of HIV-1 gp41: differential exposure of the Kennedy epitope on cell and viral membranes. PloS one, 5(12).
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2a, κ
- Specificity
- Recognizes HIV-1 gp160(738-744)
- Species Reactivity
- HIV-1
- Clone
- SAR1
- Applications
- FC, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp160 antibody has been reported in applications of Flow Cytometry, Neutralization.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP160; gp160; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone SAR1"
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01) | FC, Neut | Human IgG |
| PABL-555 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) | FC, Neut | Human IgG |
| PABL-556 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-556) | Neut | Human IgG |
| PABL-557 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) | FC, Neut | Human IgG |
| PABC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558) | ELISA, Neut | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-551 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01); Fab Fragment | Neut | Human Fab |
| PFBL-552 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02); Fab Fragment | Neut | Human Fab |
| PFBL-553 | Human Anti-HIV-1 gp160 Recombinant Antibody; Fab Fragment (PFBL-553) | Neut | Human Fab |
| PFBL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01); Fab Fragment | Neut | Human Fab |
| PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-075LC | Anti-HIV-1 gp160 Recombinant Antibody (24G3) | WB, ELISA | Human antibody |
| MRO-091LC | Anti-HIV-1 gp160 Recombinant Antibody (MAb CL1) | ELISA | Human antibody |
| MRO-100LC | Anti-HIV-1 gp160 Recombinant Antibody (N7019b) | ELISA | Human antibody |
| MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
| MRO-080LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (81C7) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
| MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
| MRO-089LC | Anti-HIV-1 gp160 Recombinant Antibody (2H8) | ELISA | Mouse antibody |
| MRO-086LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1C1) | ELISA | Mouse antibody |
| MRO-087LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1H9) | ELISA | Mouse antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3966CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 88-158/022); scFv Fragment | ELISA, WB, IHC, IF | Mouse scFv |
| MRO-3967CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone WR316); scFv Fragment | ELISA | Mouse scFv |
| MRO-3968CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone WR320); scFv Fragment | Neut | Mouse scFv |
| MRO-3969CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone B18); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3970CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone B20); scFv Fragment | ELISA, WB | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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