Mouse Anti-HIV-1 pol Recombinant Antibody (clone 17 (mAb17)) (CAT#: MRO-4264CQ)
Recombinant mouse antibody to Pol(740-750). Epitope of the antibody mapped to helix-turn-helix motif in the N-term domain of Integrase, positions 25-35 - Zn binding stabilizes the Integrase. mAb17 inhibit Integrase activity.
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ELISA
Figure 1 Structural and functional domains of HIV-1 IN and its interaction with mAb17.
The inhibitions of the processing activity of HIV-1 IN by mAb17 and Fab17 and control mAb (aMOPC12).
Yi, J., Arthur, J. W., Dunbrack, R. L., & Skalka, A. M. (2000). An inhibitory monoclonal antibody binds at the turn of the helix-turn-helix motif in the N-terminal domain of HIV-1 integrase. Journal of Biological Chemistry, 275(49), 38739-38748.
Specifications
- Immunogen
- Rec integrase
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Recognizes HIV-1 Pol(740-750)
- Species Reactivity
- HIV-1
- Clone
- 17 (mAb17)
- Applications
- ELISA, WB, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 pol antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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MHC Tetramer Products for Virology
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1749 | APC-A*02:01/HIV-1 pol (KVAEIVHFL) MHC Tetramer | FCM | |
| MHC-CN0825 | PE-A*02:01/HIV-1 pol (VIYHYVDDL) MHC Tetramer | FCM, IHC | |
| MHC-CN0826 | APC-A*02:01/HIV-1 pol (VIYHYVDDL) MHC Tetramer | FCM, IHC | |
| MHC-CN0827 | FITC-A*02:01/HIV-1 pol (VIYHYVDDL) MHC Tetramer | FCM, IHC | |
| MHC-CN0828 | A*02:01/HIV-1 pol (VIYHYVDDL) MHC Tetramer | FCM, IHC |
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