Monkey Anti-HIV gp41 Recombinant Antibody (clone B402) (CAT#: FAMAB-0262JF)
Provided is a monoclonal antibody (clone B402) specially binds to SIV gp41. This Rhesus macaque anti-gp41 antibody (B402) will be useful to analyze the mechanism of broad neutralization using the SIV macaque model.
Specific Inquiry
ELISA
Figure 1 ELISA binding of mAb to gp140, gp120, gp41.
Error bars denote one standard error of the mean (SEM).
Huang, J., Ofek, G., Laub, L., Louder, M. K., Doria-Rose, N. A., Longo, N. S., ... & Alam, S. M. (2012). Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature, 491(7424), 406-412.
IHC
Figure 2 The mechanism of complement‐mediated inhibition of antibody binding to HIV gp41.
Original magnification ×200.
Hidvegi, T., Prohászka, Z., Ujhelyi, E., Thielens, N. M., Dierich, M. P., Hampl, H., ... & Füst, G. (1993). Studies on the mechanism of complement‐mediated inhibition of antibody binding to HIV gp41. Clinical & Experimental Immunology, 94(3), 490-493.
FC
Figure 3 Staining of HIV-infected and uninfected cells by mAbs to gp41 cytoplasmic domain.
The gp41 mAbs were incubated at the concentrations shown with HIV-l-infected H9 cells which had been pretreated or not with sCD4.
Sattentau, Q. J., Zolla-Pazner, S., & Poignard, P. (1995). Epitope exposure on functional, oligomeric HIV-1 gp41 molecules. Virology, 206(1), 713-717.
WB
Figure 4 Immunoreactivity of a HIV antibody-positive serum with different ENV(80) subfragments.
M15 cells harbouring pDMI,1 and in addition the plasmid constructs encoding the hybrid proteins.
Sattentau, Q. J., Zolla-Pazner, S., & Poignard, P. (1995). Epitope exposure on functional, oligomeric HIV-1 gp41 molecules. Virology, 206(1), 713-717.
Specifications
- Immunogen
- SIVsmH636FC
- Host Species
- Monkey
- Derivation
- Rhesus Macaque phage display Fab library
- Type
- Monkey IgG
- Specificity
- HIV gp41
- Species Reactivity
- SIV
- Clone
- B402
- Applications
- WB, ELISA, IHC, FC
- Related Disease
- HIV-1 infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV gp41 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- ENV; Gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp41; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-471 | Recombinant Anti-HIV gp41 Antibody | ELISA, IP, FuncS | IgG |
| MHH-471 | Recombinant Human Anti-HIV gp41 Antibody | RIA, WB, FuncS | IgG |
| PABL-139 | Human Anti-HIV gp41 (596-606) Recombinant Antibody (clone 7B2) | Neut, FC, FuncS | Human IgG1, κ |
| HPAB-1987-FY | Human Anti-HIV gp41 Recombinant Antibody (clone Z13) | ELISA, FC | Human IgG, κ |
| FAMAB-0099WJ | Human Anti-HIV gp41 Recombinant Antibody (clone 120-16) | ELISA | Human IgG2 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-471-S(P) | Recombinant Anti-HIV gp41 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| MHH-471-S(P) | Recombinant Human Anti-HIV gp41 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| HPAB-1987-FY-S(P) | Human Anti-HIV gp41 Recombinant Antibody (clone Z13); scFv Fragment | FC, Neut | Human scFv |
| FAMAB-0082WJ-S(P) | Human Anti-HIV gp41 Recombinant Antibody (clone NO.86); scFv Fragment | ELISA, WB | Human scFv |
| FAMAB-0099WJ-S(P) | Human Anti-HIV gp41 Recombinant Antibody (clone 120-16); scFv Fragment | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-471-F(E) | Recombinant Human Anti-HIV gp41 Antibody Fab Fragment | IP, IF, Biosensors, FuncS | Fab |
| PFBL-139 | Human Anti-HIV gp41 (596-606) Recombinant Antibody (clone 7B2); Fab Fragment | Neut, FC, FuncS | Human Fab |
| HPAB-1987-FY-F(E) | Human Anti-HIV gp41 Recombinant Antibody (clone Z13); Fab Fragment | FC, Neut | Human Fab, κ |
| FAMAB-0099WJ-F(E) | Human Anti-HIV gp41 Recombinant Antibody (clone 120-16); Fab Fragment | ELISA | Human Fab |
| FAMAB-0262JF-F(E) | Monkey Anti-HIV gp41 Recombinant Antibody (clone B402); Fab Fragment | FC, ELISA, FuncS | Monkey Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-092CT | Human Anti-HIV gp41 Recombinant Antibody (TAB-092CT) | ELISA, Neut | Human IgG1 |
| TAB-092CT-F(E) | Human Anti-HIV gp41 Recombinant Antibody; Fab Fragment (TAB-092CT-F(E)) | ELISA, Neut | Human Fab |
| PABX-064 | Human Anti-HIV gp41 Recombinant Antibody (clone Z13e1) | WB, Neut, FuncS, ELISA | Human IgG1, λ |
| PABX-064-S (P) | Recombinant Human Anti-gp41 Antibody scFv Fragment (Z13e1) | WB, Neut, FuncS | scFv |
| PABX-064-F (E) | Recombinant Human Anti-gp41 Antibody Fab Fragment (Z13e1) | WB, Neut, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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