Rabbit Anti-HLA-DRB1 Recombinant Antibody (clone R02-4K1) (CAT#: VS3-XY3381)
This is a recombinant rabbit antibody targeting the human HLA-DRB1 (Major histocompatibility complex, class II, DR beta 1), which typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human HLA-DRB1
- Species Reactivity
- Human
- Clone
- R02-4K1
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Multiple Sclerosis; Sarcoidosis 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- SS1; DRB1; HLA-DRB; HLA-DR1B
- Gene ID
- 3123
- UniProt ID
- P01911
- Long Name
- Major histocompatibility complex, class II, DR beta 1
- Cellular Localization
- Cell membrane, Lysosome membrane, Endoplasmic reticulum membrane
- Post Translation Modifications
- Ubiquitinated by MARCHF1 and MARCHF8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHCII. (P01911-DRB1_HUMAN)
Glycosylation at Asn48 (NX_P01911 [NX_P01911-1])
Ubiquitination at Lys254 (NX_P01911 [NX_P01911-1])
Glycosylation from GlyConnect DRB1_HUMAN (1369, 1370, 1371, 1372, 1373, 1374, 1375, 1376)
Glycosylation from GlyGen (P01911) 1 site
- Protein Refseq
- XP_024308321.1
- Function
- A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HLA-DRB1"
Select a product category from the dropdown menu below to view related products.
Please select product type
ScFv Antibody Products
Humanized Antibody Products
Rabbit Monoclonal Antibody Products
MHC Tetramer Products for Cancer
IgG Antibody Products
Fab Antibody Products
ADCC Enhanced Antibody Products
Non-Human Primate (NHP) Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1090z-S(P) | Recombinant Anti-Human HLA-DRB1 Antibody scFv Fragment | WB, FC, FuncS | scFv |
| HPAB-0023-YC-S(P) | Human Anti-HLA-DRB1 Recombinant Antibody (clone huA33); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0024-YC-S(P) | Human Anti-HLA-DRB1 Recombinant Antibody (clone de-immunized huA33); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0025-YC-S(P) | Human Anti-HLA-DRB1 Recombinant Antibody (clone HD4); scFv Fragment | Cyt, WB | Human scFv |
| HPAB-0026-YC-S(P) | Human Anti-HLA-DRB1 Recombinant Antibody (clone HD8); scFv Fragment | Cyt, WB | Human scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS3-XY3381. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: WB, IF, FuncS
-2.png)
Application: IB, ELISA, FC, FuncS
Application: FC, IA, IF, IP, IHC, FuncS
-4.jpg)
Application: FC
Application: ELISA, Cyt, PP, Inhib
Application: ELISA, Activ, Block
Application: ELISA, FC, FuncS
Application: ELISA, Neut, FuncS
Application: WB, IHC-Fr, IHC-P, ICC, IF
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
