Rabbit Anti-HLA-DRB1 Recombinant Antibody (clone R02-4K1)
CAT#: VS3-XY3381
This is a recombinant rabbit antibody targeting the human HLA-DRB1 (Major histocompatibility complex, class II, DR beta 1), which typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
Normal Tissue
Figure 2 Tonsil
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human HLA-DRB1
- Species Reactivity
- Human
- Clone
- R02-4K1
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Multiple Sclerosis; Sarcoidosis 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- SS1; DRB1; HLA-DRB; HLA-DR1B
- Gene ID
- 3123
- UniProt ID
- P01911
- Long Name
- Major histocompatibility complex, class II, DR beta 1
- Cellular Localization
- Cell membrane, Lysosome membrane, Endoplasmic reticulum membrane
- Post Translation Modifications
- Ubiquitinated by MARCHF1 and MARCHF8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHCII. (P01911-DRB1_HUMAN)
Glycosylation at Asn48 (NX_P01911 [NX_P01911-1])
Ubiquitination at Lys254 (NX_P01911 [NX_P01911-1])
Glycosylation from GlyConnect DRB1_HUMAN (1369, 1370, 1371, 1372, 1373, 1374, 1375, 1376)
Glycosylation from GlyGen (P01911) 1 site
- Protein Refseq
- XP_024308321.1
- Function
- A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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