Rabbit Anti-HMGCS2 Recombinant Antibody (VS13-YC537)
CAT#: VS13-YC537
The Rabbit Anti-HMGCS2 Recombinant Antibody is specific for human, mouse and rat HMGCS2. HMGCS2 is a mitochondrial enzyme initiating ketogenesis, providing lipid-derived energy during carbohydrate deprivation. Mutations cause HMG-CoA synthase deficiency, with this gene presenting alternative splicing variants. The anti-HMGCS2 antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27423/2048_B2_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/1395_F6_3_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (OE19, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134240-HMGCS2
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat HMGCS2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 10 mM PBS (pH 7.4) containing 150 mM NaCl, 50% Glycerol and 0.05% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Target
- Alternative Names
- 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2; EC 2.3.3.10; 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase 2 (Mitochondrial); 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial); 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase; HMG-CoA Synthase;
- Gene ID
- 3158
- UniProt ID
- P54868
- Long Name
- 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "HMGCS2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0257MZ | Chicken Anti-HMGCS2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1637 | Rabbit Anti-HMGCS2 Recombinant Antibody (clone DS1637AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS4-WK223 | Rabbit Anti-HMGCS2 Recombinant Antibody (clone 19C11) | ELISA, WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3213 | Anti-HMGCS2 Immunohistochemistry Kit | IHC |
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