CytoStream™ Rabbit Anti-HMOX1 Recombinant Antibody (VS13-YC539)
CAT#: VS13-YC539
The CytoStream™ Rabbit Anti-HMOX1 Recombinant Antibody is specific for human HMOX1. HMOX1 is an essential enzyme in heme catabolism, producing biliverdin and carbon monoxide. With induced activity, it belongs to a family including a constitutive isozyme, crucial in responding to various substances. The anti-HMOX1 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/635/51_B8_2_selected.jpg
Normal Tissue
Figure 2 Colon
Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17444/39144_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17444/39144_A_7_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17444/39144_A_7_8.jpg
Normal Tissue
Figure 5 High expression in spleen
Cells in red pulp Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17444/39144_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (BEWO, GAMG, U-138 MG, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100292-HMOX1
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Specifications
- Immunogen
- Recombinant human HO-1, aa 227-276.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human HMOX1
- Species Reactivity
- Human
- Applications
- WB, IHC-P, IP, FC
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Heme Oxygenase 1; Heme Oxygenase (Decycling) 1; HO-1; Heat Shock Protein, 32-KD; EC 1.14.14.18; EC 1.14.99.3;
- Gene ID
- 3162
- UniProt ID
- P09601
- Long Name
- Heme Oxygenase 1
- Sequence Similarities
- Belongs to the heme oxygenase family.
- Cellular Localization
- Microsome; Endoplasmic reticulum membrane
- Protein Refseq
- NP_002124.1
- Function
- Heme oxygenase 1:
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:7703255, PubMed:11121422).
Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707).
(Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy.
Heme oxygenase 1 soluble form:
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "HMOX1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0877CT | Recombinant Mouse anti-Rat HMOX1 Monoclonal antibody (IP-2-3) | ELISA, WB | |
| MRO-0728-CN | Rabbit Anti-HMOX1 Recombinant Antibody (clone CBACN-265) | WB, IHC, IP, FC | Rabbit IgG |
| MRO-1925-CN | Rabbit Anti-HMOX1 Polyclonal Antibody (MRO-1925-CN) | WB, IF, IHC | Rabbit IgG |
| VS3-CJ541 | Rabbit Anti-HMOX1 Recombinant Antibody (VS3-CJ541) | WB, IHC, IP, FC | Rabbit IgG |
| VS3-FY687 | Recombinant Rabbit Anti-HMOX1 Antibody (clone R02-6C1) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-912CQ | Mouse Anti-HMOX1 Recombinant Antibody (clone GTS-1) | ELISA, IHC-Fr, IHC-P, Inhib, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1639 | Rabbit Anti-HMOX1 Recombinant Antibody (clone DS1639AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0841 | PE-A*02:01/Human HMOX1 (QLFEELQEL) MHC Tetramer | FCM, IHC | |
| MHC-CN0842 | APC-A*02:01/Human HMOX1 (QLFEELQEL) MHC Tetramer | FCM, IHC | |
| MHC-CN0843 | FITC-A*02:01/Human HMOX1 (QLFEELQEL) MHC Tetramer | FCM, IHC | |
| MHC-CN0844 | A*02:01/Human HMOX1 (QLFEELQEL) MHC Tetramer | FCM, IHC | |
| MHC-CN0845 | PE-A*03:01/Human HMOX1 (QVLKKIAQK) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY257 | Mouse Anti-NHP HMOX1 Recombinant Antibody (clone 1F12-A6) | WB, IHC, IF | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1036 | Anti-HMOX1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3218 | Anti-Mouse HMOX1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3217 | Anti-Human HMOX1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3219 | Anti-Bovine HMOX1 Immunohistochemistry Kit | IHC |
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