Rabbit Anti-HNRNPU Recombinant Antibody (clone R05-7N7)
CAT#: VS3-XY3383
It is a recombinant rabbit antibody targeting the HNRNPU (Heterogeneous nuclear ribonucleoprotein U), which plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs. It reacts with human, mouse and rat HNRNPU. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human bronchus
Immunohistochemical staining of human bronchus shows strong nuclear positivity in respiratory epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41057/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong nuclear positivity in cerebellar tissues.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11532/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58707/136687_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58707/136687_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58707/136687_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58707/136687_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58707/136687_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58707/136687_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153187-HNRNPU
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat HNRNPU
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-7N7
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Mitochondrial Complex Iv Deficiency, Nuclear Type 11
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- SAFA; DEE54; HNRPU; SAF-A; U21.1; pp120; EIEE54; GRIP120; hnRNP U; HNRNPU-AS1
- Gene ID
- 3192
- UniProt ID
- Q00839
- Long Name
- Heterogeneous nuclear ribonucleoprotein U
- Cellular Localization
- Nucleus, Chromosome, Cytoplasm, cytoskeleton
- Post Translation Modifications
- Citrullinated by PADI4. (Q00839-HNRPU_HUMAN)
Ubiquitination at Lys9, Lys186, Lys265, Lys352, Lys464, Lys516, Lys524, Lys536, Lys544, Lys551, Lys565, Lys602, Lys635, Lys664, and Lys814 (NX_Q00839 [NX_Q00839-1])
Modification sites at PhosphoSitePlus (Q00839)
Glycosylation from GlyGen (Q00839) 8 sites, 1 O-linked glycan (7 sites)
- Protein Refseq
- NP_004492.2
- Function
- DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, 18082603, 19029303, 22325991, 25986610, 28622508).
Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
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- Product Name
Recommended Dilution Buffer
- CAT
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Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3712z | Mouse Anti-HNRNPU Recombinant Antibody (clone 25H9) | WB, ICC, IF, IP | Mouse IgG1 |
| MOB-2378MZ | Recombinant Mouse Anti-Human HNRNPU Antibody (clone 4H7) | ELISA, FC, ICC, IF, IHC-P, IP, WB | Mouse antibody |
| ZG-0438J | Mouse Anti-HNRNPU Recombinant Antibody (ZG-0438J) | WB | Mouse IgG |
| ZG-0439J | Mouse Anti-HNRNPU Recombinant Antibody (ZG-0439J) | WB | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1650 | Rabbit Anti-HNRNPU Recombinant Antibody (clone DS1650AB) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY128 | AbPlus™ Anti-HNRNPU Magnetic Beads (3G6) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY256 | Mouse Anti-NHP HNRNPU Recombinant Antibody (clone 3G6) | WB, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1050 | Anti-HNRNPU Immunohistochemistry Kit | IHC | |
| VS-0525-XY3246 | Anti-Human HNRNPU Immunohistochemistry Kit | IHC |
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