Provided are antibodies bind to the NIm-IA site of HRV14, which is the β-B–β-C loop of the viral capsid protein VP1. Two antibodies, Fab17-IA (Fab17) and Fab12-IA (Fab12), bind bivalently to the virion surface and strongly neutralize viral infectivity whereas Fab1-IA (Fab1) strongly aggregates and weakly neutralizes virions. All of the antibodies contact a significant proportion of the canyon region and directly overlap much of the receptor (intercellular adhesion molecule 1 [ICAM-1]) binding site. Fab1, however, does not contact the same residues on the upper south wall (the side facing away from fivefold axes) at the receptor binding region as do Fab12 and Fab17. All three antibodies cause some stabilization of HRV14 against pH-induced inactivation; thus, stabilization may be mediated by invariant contacts with the canyon.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0531-YC | Recombinant Mouse Anti-HRV14 NIm-IA Antibody (MAb17-IA) | ELISA, Neut (strong), Precipitation (weak) | Mouse IgG |
HPAB-M0532-YC | Recombinant Mouse Anti-HRV14 NIm-IA Antibody (MAb12-IA) | Neut (strong), Precipitation (weak) | Mouse IgG2a |
HPAB-M0533-YC | Recombinant Mouse Anti-HRV14 NIm-IA Antibody (MAb1-IA) | Neut (weak), Precipitation (strong) | Mouse lgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0531-YC-S(P) | Recombinant Mouse Anti-HRV14 NIm-IA Antibody scFv Fragment (MAb17-IA) | ELISA, Neut (strong), Precipitation (weak) | Mouse scFv |
HPAB-M0532-YC-S(P) | Recombinant Mouse Anti-HRV14 NIm-IA Antibody scFv Fragment (MAb12-IA) | Neut (strong), Precipitation (weak) | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0531-YC-F(E) | Recombinant Mouse Anti-HRV14 NIm-IA Antibody Fab Fragment (MAb17-IA) | ELISA, Neut (strong), Precipitation (weak) | Mouse Fab |
HPAB-M0532-YC-F(E) | Recombinant Mouse Anti-HRV14 NIm-IA Antibody Fab Fragment (MAb12-IA) | Neut (strong), Precipitation (weak) | Mouse Fab |
HPAB-M0533-YC-F(E) | Recombinant Mouse Anti-HRV14 NIm-IA Antibody Fab Fragment (MAb1-IA) | Neut (weak), Precipitation (strong) | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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