Mouse Anti-HSPA1L Recombinant Antibody (VS3-CJ888)
CAT#: VS3-CJ888
This product is a mouse antibody that recognizes human, mouse, and rat HSPA1L.
Gene Expression
Normal Tissue
Figure 1 High expression in testis
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43285/102707_A_6_6_val_selected.jpg
Normal Tissue
Figure 2 Low expression in endometrium 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43285/102707_B_4_3_val_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43285/102707_A_8_3.jpg
Normal Tissue
Figure 4 Testis
Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Low Intensity: Weak
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43285/102707_A_5_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A549, EFO-21, HEK93)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000204390-HSPA1L
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Specifications
- Immunogen
- KLH-conjugated synthetic peptide encompassing a sequence of human HSP70
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse, Rat HSPA1L
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IF, IHC
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 30% Glycerol, 0.87% NaCl, 0.42% Potassium phosphate, pH7.3.
- Preservative
- 0.01% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipped at 4°C
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:1000-1:2000), Immunocytochemistry/Immunofluorescence (1:100-1:200), Immunohistochemistry (1:50-1:200).
Target
- Alternative Names
- HSP70T; hum70t; HSP70-1L; HSP70-HOM
- Gene ID
- 3305
- UniProt ID
- P34931
- Sequence Similarities
- Belongs to the heat shock protein 70 family.
- Cellular Localization
- Blood microparticle, Cytoplasm, Cytosol, Mitochondrial matrix, Nucleoplasm, Nucleus, Plasma membrane
- Protein Refseq
- NP_005518.3
- Function
- Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).
Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "HSPA1L"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1144MZ | Recombinant Mouse Anti-Human HSPA1L Antibody | IHC-P | Mouse antibody |
| MRO-0785-CN | Mouse Anti-HSPA1L Recombinant Antibody (clone 7D1) | WB, IHC | Mouse IgG1 |
| VS3-XY829 | Mouse Anti-HSPA1L Recombinant Antibody (clone 7D3) | WB, ICC, IHC, FC | Mouse IgG1 |
| VS4-WK229 | Mouse Anti-HSPA1L Recombinant Antibody (VS4-WK229) | ELISA, WB, IHC, IF | Mouse IgG |
| VS3-WK1571 | Mouse Anti-HSPA1L Recombinant Antibody (clone 3G10) | WB, IHC-P, IF, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1072 | Anti-HSPA1L Immunohistochemistry Kit | IHC | |
| VS-0525-XY3321 | Anti-Mouse HSPA1L Immunohistochemistry Kit | IHC | |
| VS-0525-XY3320 | Anti-Human HSPA1L Immunohistochemistry Kit | IHC |
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