Anti-HSPA4 (clone G6A) Recombinant Antibody Coupled Liposome (VS-1024-FY184)
CAT#: VS-1024-FY184
HSPA4 is a heat shock protein that aids in protecting cancer cells from stress-induced death. The anti-HSPA4 antibody conjugated liposome targets this protein to enhance apoptosis in melanoma cells. By disrupting the protective mechanisms of cancer cells, this method may increase treatment sensitivity. Preliminary findings indicate a potential for improved outcomes in melanoma patients.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10023/100_C10_1_selected.jpg
Subcellular Location
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows nuclear and cytoplasmic positivity in cells in seminiferous ducts and Leydig cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10023/24928_A_6_6_selected.jpg
Subcellular Location
Figure 3 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic and nuclear positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25529/60475_A_1_5_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10023/101_C10_1_red_green.jpg
Subcellular Location
Figure 5 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10023/82_C10_1_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10023/25173_B_7_5.jpg
Normal Tissue
Figure 7 Colon
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10023/24928_A_7_3.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10023/24928_A_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000170606-HSPA4
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- G6A
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody specifically engineered to target and bind to the heat shock protein HSPA4. HSPA4, also known as Heat Shock 70 kDa Protein 4, plays a crucial role in cellular stress responses and protein folding. By using advanced recombinant techniques, this antibody has been optimized for enhanced specificity and affinity towards HSPA4, making it a powerful tool for research and diagnostic applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- HSPA4
- Introduction
- HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Ischemia and Leishmaniasis. Among its related pathways are Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics and CCR5 Pathway in Macrophages. An important paralog of this gene is HSPA4L.
- Alternative Names
- Heat Shock Protein Family A (Hsp70) Member 4; Heat Shock 70-Related Protein APG-2; Heat Shock 70kDa Protein 4; Heat Shock 70kD Protein 4; Hsp70 RY; Hsp70RY; Epididymis Secretory Sperm Binding Protein Li 5a; Heat Shock 70 KDa Protein 4; Heat Shock Protein, 110 KDa
- Full Name
- Heat Shock Protein Family A (Hsp70) Member 4
- Gene ID
- 3308
- UniProt ID
- P34932
- Sequence Similarities
- Belongs to the heat shock protein 70 family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys44, Lys53, Lys61, Lys124, Lys194, Lys221, Lys235, Lys305, Lys422, Lys430, Lys573, Lys638, Lys674, Lys679, Lys686, Lys697, Lys704, Lys711, Lys719, Lys736, Lys748, Lys754, and Lys773 ( NX_P34932 [NX_P34932-1] )
Modification sites at PhosphoSitePlus ( P34932 )
Glycosylation from GlyGen (P34932) 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_054208468.1; NP_002145.3
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Datasheet
MSDS
COA
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| MRO-0787-CN | Rabbit Anti-HSPA4 Recombinant Antibody (clone CBACN-296) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-A1209-YJ | Human Anti-HSPA4 Recombinant Antibody (clone G6A) | ELISA, IF | Human IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1694 | Rabbit Anti-HSPA4 Recombinant Antibody (clone DS1694AB) | WB, IP, ICC, ELISA, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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