Human Anti-IAV HA Vaccinal Antibody (VS-0625-XY50)

CAT#: VS-0625-XY50

Engineered to target IAV hemagglutinin head, this vaccinal antibody supports ELISA and neutralization (Neut) assays. Fc modification induces vaccine-like effects and enhances antiviral efficacy for potent virus neutralization.

Specifications

  • Target
  • IAV HA
  • Host Animal
  • Human
  • Applications
  • ELISA; Neut
  • Specificity
  • IAV HA
  • Species Reactivity
  • IAV
  • Type
  • Human IgG
  • Purity
  • >95%, determined by SDS-PAGE
  • Purification
  • Protein A purified
  • Format
  • Liquid
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.

Target

  • Introduction
  • Hemagglutinin are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus attachment to cells requires their interaction with several virus HAs. Receptor-bound virus is transferred into endosomes where membrane fusion by HAs is activated at pH between 5 and 6.5, depending on the strain of virus. Fusion activity requires extensive rearrangements in HA conformation that include extrusion of a buried "fusion peptide" to connect with the endosomal membrane, form a bridge to the virus membrane, and eventually bring both membranes close together.
  • Related Disease
  • Influenza
  • Alternative Names
  • Influenza virus Hemagglutinin
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Datasheet

MSDS

COA

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Secondary Antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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