Human Anti-ICOS Recombinant Antibody (clone JMab-136) (CAT#: HPAB-0052-YJ)
This product is a recombinant human monoclonal antibody that recognizes human AILIM. The antibody AIH5D3 (JMab-136) is cross-reactive with human AILIM, Mouse AILIM, and Rat AILIM. This antibody is capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that this antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/34865/1813_D4_33_selected.jpg

(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32575/ihc_selected.jpg

(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/34865/1886_G11_2_blue_red_green.jpg

(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32575/78503_A_9_8.jpg

(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32575/78503_A_6_8.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163600-ICOS

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163600-ICOS
Specifications
- Immunogen
- Cell membrane fraction prepared from recombinant cells (HPB-ALL cells or CHO cells) overexpressing human AILIM.
- Host Species
- Human
- Type
- Human IgG2, κ
- Specificity
- Human
- Species Reactivity
- Human, Mouse, Rat
- Clone
- JMab-136
- Applications
- ELISA
- Related Disease
- Disorders related to the delayed allergy
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- AILIM; CD278; CVID1; activation-inducible lymphocyte immunomediatory molecule; inducible T-cell co-stimulator; inducible costimulator; AIH5D3 (JMab-136)
- Gene ID
- 29851
- UniProt ID
- Q9Y6W8
Related Resources
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone JMab-136"
See other products for "ICOS"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1124z | Mouse Anti-ICOS Recombinant Antibody (clone 41C5) | FC, IHC, IP, FuncS | Mouse IgG1, κ |
MOB-2311MZ | Recombinant Mouse Anti-Human ICOS Antibody (clone 26-525), APC-Conjugated | FC | Mouse antibody |
HPAB-0109-CN | Hamster Anti-ICOS Recombinant Antibody (HPAB-0109-CN) | ELISA, FC, IHC | Hamster IgG |
HPAB-0110-CN | Hamster Anti-ICOS Recombinant Antibody (HPAB-0110-CN) | ELISA, FC, IHC | Hamster IgG |
HPAB-0073-WJ | Human Anti-ICOS Recombinant Antibody (HPAB-0073-WJ) | ELISA, IHC, Inhib, FC | Human IgG |
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