Anti-IFNGR1 Antibody Prodrug, Protease Activated (gamma R38)
CAT#: VS-1025-YC204
The Anti-IFNGR1 Antibody Prodrug, Protease Activated (gamma R38) is an antibody prodrug comprised of a recombinant mouse antibody targeting human IFNGR1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IFNGR1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IFNGR1 effectively. IFNGR1 is a subunit of the receptor for Interferon-gamma (IFN-γ), a key cytokine in the anti-tumor immune response. Loss-of-function mutations in IFNGR1 are a mechanism of immune evasion used by tumor cells to become unresponsive to IFN-γ-mediated signaling and destruction.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29213/273_A10_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong membranous positivity in cells in red pulp.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63871/148756_B_9_4_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous and cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25889/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63871/148756_B_8_5.jpg
Normal Tissue
Figure 5 Lung
Macrophages Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63871/148756_A_1_4.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000027697-IFNGR1
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human IFNGR1
- Target
- IFNGR1
- Species Reactivity
- Human
- Isotype
- IgG
- Clone
- gamma R38
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
- Alternative Names
- CD119; IFNGR; IMD27A; IMD27B
- Gene ID
- 3459
- UniProt ID
- P15260
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Related Diseases
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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