Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-736)

Name: Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-736)
SKU: AFC-TAB-736
Rating: 5 (1 reviews)

CAT#: AFC-TAB-736

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to IGF1R. It is a humanized monoclonal antibody designed for the treatment of cancers.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg

Normal Tissue Figure 6 Heart muscle

Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
FC, IP, ELISA, Neut, FuncS, IF

Conjugate
Unconjugated

Generic Name
Dalotuzumab

Related Disease
Solid tumors

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor;

Gene ID
3480

UniProt ID
P08069

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

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Biosimilar Overview

Please refer to Dalotuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Dalotuzumab.

Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance

Type I Diabetes Mellitus

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-736.pdf

MSDS

MSDS - AFC-TAB-736.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Dalotuzumab"

DrugMonitor™ Anti-Dalotuzumab Antibody (VS-1224-YC333)
Dalotuzumab has undergone investigation for breast cancer, non-small cell lung cancer, and metastatic colorectal cancer treatment. The DrugMonitor™ Anti-Dalotuzumab Antibody (VS-1224-YC333) is an anti-drug antibody (ADA) against Dalotuzumab. This drug-based antibody is raised in mice immunized with the Dalotuzumab. The anti-Dalotuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Dalotuzumab in samples.

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CAT	Product Name	Application	Type
NABL-091	Recombinant Anti-human IGF1R VHH Single Domain Antibody	WB, ELISA, IHC, FC, FuncS	Llama VHH
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HPAB-1545-FY	Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1545-FY)	WB, ELISA	Llama VHH
HPAB-1546-FY	Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1546-FY)	WB, ELISA	Llama VHH
HPAB-1547-FY	Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1547-FY)	WB, ELISA	Llama VHH

CAT	Product Name	Application	Type
AGTO-L024E	IGF1-PE immunotoxin	Cytotoxicity assay, Functional assay
AGTO-L024D	IGF1-DT immunotoxin	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
AFC-371CL	Afuco™ Anti-Human IGF1R Antibody, ADCC Enhanced (AFC-371CL)	ELISA	ADCC enhanced antibody
AFC-TAB-199	Afuco™ Anti-IGF1R Recombinant Antibody (AFC-TAB-199), ADCC Enhanced	FC, IP, ELISA, Neut, FuncS, IF	Human IgG1, κ
AFC-TAB-209	Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-209)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-078	Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-078)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-232	Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-232)	IF, IP, Neut, FuncS, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
PSBL-591	Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-14); scFv Fragment	WB, ELISA, FuncS	Mouse scFv
PSBL-592	Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-7); scFv Fragment	WB, ELISA, FuncS	Mouse scFv
HPAB-1204-FY-F(E)	Mouse Anti-IGF1R Recombinant Antibody (clone 2C6); scFv Fragment	Inhib, ELISA	Mouse scFv
HPAB-1205-FY-F(E)	Mouse Anti-IGF1R Recombinant Antibody (clone 9H2); scFv Fragment	Inhib, ELISA	Mouse scFv
HPAB-1277WJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 1H7); scFv Fragment	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-009ZJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-009ZJ-S(P))	ELISA, FC	Mouse scFv
TAB-010ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (6E11)	ELISA, Neut, FC, IHC
TAB-011ZJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-011ZJ-S(P))	ELISA, FC, WB, Inhib	Mouse scFv
TAB-012ZJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-012ZJ-S(P))	ELISA, FC, WB, Inhib	Mouse scFv
TAB-014ZJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-014ZJ-S(P))	ELISA, FC, Inhib, IP	Mouse scFv

CAT	Product Name	Application	Type
TAB-035ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-035ZJ-S(P))	ELISA, FC	Humanized scFv
TAB-036ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (H0L0 IgGIm(AA))	ELISA, Neut, FC, IHC	Humanized antibody
TAB-037ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (H1L0 IgGIm(AA))	ELISA, Neut, FC, IHC	Humanized antibody
TAB-038ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-038ZJ-S(P))	ELISA, FC, Inhib, IP	Humanized scFv
TAB-051ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-051ZJ-S(P))	ELISA, IHC, IF, WB	Human scFv

CAT	Product Name	Application	Type
TAB-052ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (TAB-052ZJ-S(P))	ELISA, FC, IF, IP	Human antibody
TAB-053ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (IR3)	ELISA, FC, WB	Human antibody
TAB-054ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (IR10)	ELISA, FC, WB	Human antibody
TAB-055ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-055ZJ-S(P))	ELISA	Human scFv
TAB-056ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-056ZJ-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-084ZJ-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-084ZJ-F(E))	ELISA, FC	Chimeric (mouse/human) Fab
TAB-085ZJ-F(E)	Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11c)	ELISA, Neut, FC, IHC	Chimeric antibody (mouse/human)
TAB-086ZJ-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-086ZJ-F(E))	ELISA, FC, Inhib, IP	Chimeric (mouse/human) Fab
TAB-087ZJ-F(E)	Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch7C2)	ELISA	Chimeric antibody (mouse/human)
TAB-093ZJ-F(E)	Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch9E11)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
BRD-0103MZ	Chicken Anti-CD221 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-1075CQ	Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3)	FC, IP, Neut, ICC, IF	Mouse IgG1
NEUT-1076CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111)	ELISA, Neut, WB	Mouse IgG1
NEUT-1081CQ	Mouse Anti-IGF1R Recombinant Antibody (clone CBL453)	WB, ELISA, Neut	Mouse IgG1
NEUT-1082CQ	Mouse Anti-IGF1R Recombinant Antibody (clone CBL080)	Neut, WB	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-1077CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 1H7)	FC, Block, IHC, IP, WB	Mouse IgG1, κ
NEUT-1078CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 24-60)	Inhib, ICC, IF, IP, WB	Mouse IgG2a, κ
NEUT-1079CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 17-69)	Inhib, IP	Mouse IgG1
NEUT-1080CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 24-57)	Inhib, IP	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-1755	Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB)	IP, ELISA	Rabbit IgG
MOR-4684	Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS)	WB, ELISA	Rabbit IgG
MOR-4685	Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
NS-041CN	Mouse Anti-IGF1R Recombinant Antibody (NS-041CN)	ELISA, WB, FC	Mouse IgG
NS-041CN-F(E)	Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E))	ELISA, WB, FC	Mouse Fab
NS-041CN-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P))	ELISA, WB, FC	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0210CQ	Human Anti-IGF1R Recombinant Antibody (clone 15H12)	ELISA, FC, Neut	Human IgG3, κ
MRO-1957-CN	Rabbit Anti-IGF1R Polyclonal Antibody (MRO-1957-CN)	WB, IHC	Rabbit IgG
HPAB-0456-YJ	Human Anti-IGF1R Recombinant Antibody (clone DB#2)	ELISA, Inhib, FuncS	Human IgG1
HPAB-0457-YJ	Human Anti-IGF1R Recombinant Antibody (clone DB#7)	ELISA, Inhib, FuncS	Human IgG1
VS7-0425-WR118	Mouse Anti-IGF1R Monoclonal Antibody (VS7-0425-WR118)	WB, IHC-P, IF, ELISA	Mouse IgG

CAT	Product Name	Application	Type
HPAB-1204-FY-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 2C6); Fab Fragment	Inhib, ELISA	Mouse Fab
HPAB-1205-FY-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 9H2); Fab Fragment	Inhib, ELISA	Mouse Fab
HPAB-1206-FY-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 6E11); Fab Fragment	ELISA	Mouse Fab
HPAB-1207-FY-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 9C7); Fab Fragment	ELISA	Mouse Fab
HPAB-2063-FY-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-2063-FY-F(E))	IA	Human Fab

CAT	Product Name	Application	Type
VS-0424-XY145	AbPlus™ Anti-IGF1R Magnetic Beads (9E11)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY20	Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera	ELISA, FC, Neut, Inhib	Human IgG1, scFv-Fc
VS-0325-FY85	Human Anti-IGF1R (clone 7C10) scFv-Fc Chimera	ELISA, FC, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application
VS-0325-XY1101	Anti-IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3431	Anti-Mouse IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3430	Anti-Human IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3432	Anti-Rat IGF1R Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0425-YC366	Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-YC108	Recombinant Anti-IGF1R (AA 62-184 x AA 283-440) Biparatopic Antibody, Tandem scFv (Clone 4-52 x Clone 45742)	ELISA	Tandem scFv
VS-0525-YC107	Recombinant Anti-IGF1R (AA 283-440 x AA 440-514) Biparatopic Antibody, Tandem scFv (Clone 45742 x Clone 24-55)	ELISA	Tandem scFv

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