Mouse Anti-IKZF1 Recombinant Antibody (clone 4B6A12)
CAT#: VS7-0425-WR129
This product is a mouse IgG2b recombinant antibody that binds to human IKZF1. The antibody 4B6A12 recognizes a specific amino acid domain of human IKZF1 (AA: 401-520). It can be used for FC assay.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35221/1779_C1_2_selected.jpg
Normal Tissue
Figure 2 High expression in tonsil
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35221/140975_A_6_8_val_selected.jpg
Normal Tissue
Figure 3 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35221/140975_B_7_5_val_selected.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35222/140899_A_8_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35222/140899_A_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, HMC-1, JURKAT, MOLT-4, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185811-IKZF1
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Specifications
- Immunogen
- Recombinant human IKZF1 (AA: 401-520) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human IKZF1
- Species Reactivity
- Human
- Clone
- 4B6A12
- Molecule Class
- Transcription Factor
- Applications
- FC
- Conjugate
- Unconjugated
- Related Disease
- Acute lymphoblastic leukemia (ALL); Immunodeficiency.
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
- Gene ID
- 10320
- UniProt ID
- Q13422
- Long Name
- IKAROS family zinc finger 1
- Cellular Localization
- Cytoplasm; Nucleus
- Post Translation Modifications
- Isopeptide bond; Phosphoprotein; Ubl conjugation
- Protein Refseq
- XP_011513360.1
- Function
- Transcription regulator of hematopoietic cell differentiation (PubMed:17934067).
Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594).
Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "IKZF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4031z | Mouse Anti-IKZF1 Recombinant Antibody (clone 20G3) | WB, FC, ICC, IP | Mouse IgG1 |
| MRO-0821-CN | Rabbit Anti-IKZF1 Recombinant Antibody (clone JB50-38) | WB, IHC, FC | Rabbit IgG |
| VS3-QX590 | Mouse Anti-IKZF1 Recombinant Antibody (clone 1A12-F2-D8) | WB, IP | Mouse IgG1 |
| VS4-WK246 | Mouse Anti-IKZF1 Recombinant Antibody (VS4-WK246) | ELISA, WB | Mouse IgG |
| VS3-FY1747 | Rabbit Anti-IKZF1 Recombinant Antibody (clone R08-5E4) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1783 | Rabbit Anti-IKZF1 Recombinant Antibody (clone DS1783AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3472 | Anti-IKZF1 Immunohistochemistry Kit | IHC |
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