Rabbit Anti-IKZF1 Recombinant Antibody (VS13-YC577)
CAT#: VS13-YC577
The Rabbit Anti-IKZF1 Recombinant Antibody is specific for human IKZF1. IKZF1, associated with lymphocyte regulation and chromatin remodeling, has overexpression linked to malignancies like leukemia, with isoform variants offering different DNA-binding capabilities. The anti-IKZF1 antibody can be used for Immunohistochemistry (1/100-1/200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35221/1779_C1_2_selected.jpg
Normal Tissue
Figure 2 High expression in tonsil
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35221/140975_A_6_8_val_selected.jpg
Normal Tissue
Figure 3 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35221/140975_B_7_5_val_selected.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35222/140899_A_8_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35222/140899_A_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, HMC-1, JURKAT, MOLT-4, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185811-IKZF1
❮
❯
Specifications
- Immunogen
- Recombinant human Ikaros.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IKZF1
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
- Related Disease
- Common Variable Immunodeficiency and Diamond-Blackfan Anemia-Like
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- IKAROS Family Zinc Finger 1
- Gene ID
- 10320
- UniProt ID
- Q13422
- Long Name
- IKAROS Family Zinc Finger 1
- Sequence Similarities
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
- Cellular Localization
- Cytoplasm; Nucleus
- Protein Refseq
- XP_011513360.1; XP_011513361.1; XP_011513362.1; XP_011513363.1; XP_011513364.1
- Function
- Transcription regulator of hematopoietic cell differentiation.
Binds gamma-satellite DNA.
Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS13-YC577. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "IKZF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1783 | Rabbit Anti-IKZF1 Recombinant Antibody (clone DS1783AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0821-CN | Rabbit Anti-IKZF1 Recombinant Antibody (clone JB50-38) | WB, IHC, FC | Rabbit IgG |
| ZG-0484J | Mouse Anti-IKZF1 Recombinant Antibody (ZG-0484J) | WB | Mouse IgG |
| ZG-0485J | Mouse Anti-IKZF1 Recombinant Antibody (ZG-0485J) | WB | Mouse IgG |
| VS3-FY1747 | Rabbit Anti-IKZF1 Recombinant Antibody (clone R08-5E4) | WB, IHC-P | Rabbit IgG |
| VS3-FY2742 | Mouse Anti-IKZF1 Recombinant Antibody (VS3-FY2742) | FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3472 | Anti-IKZF1 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: FuncS, Inhib, IP, ELISA
-2.jpg)
Application: IB, ELISA, FC, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, Inhib, FuncS
Application: ELISA, Activ, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
