Mouse Anti-IL13 Recombinant Antibody (clone mAb13.2) (CAT#: HPAB-1739-FY)

Figure 1 Cynomolgus monkey IL-13 has bioactivity and can be neutralized with antibodies.

A half-maximal concentration of human (open symbols) or NHP (solid symbols) IL-13 was combined with the indicated concentration of mAb13.2.

Figure 2 Anti–IL-13 antibody reduced total BAL inflammation in response to A suum challenge.

Animals were given IVIG or saline (control), dexamethasone (DEX), or anti–IL-13 (mAb13.2 or IMA-638). Total cells.

Bree, A., Schlerman, F. J., Wadanoli, M., Tchistiakova, L., Marquette, K., Tan, X. Y., ... & Vunnum, S. (2007). IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. Journal of Allergy and Clinical Immunology, 119(5), 1251-1257.

Figure 3 Anti–IL-13 antibody reduced total BAL inflammation in response to A suum challenge.

Animals were given IVIG or saline (control), dexamethasone (DEX), or anti–IL-13 (mAb13.2 or IMA-638). Neutrophils.

Bree, A., Schlerman, F. J., Wadanoli, M., Tchistiakova, L., Marquette, K., Tan, X. Y., ... & Vunnum, S. (2007). IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. Journal of Allergy and Clinical Immunology, 119(5), 1251-1257.

Figure 4 Serum concentration of anti–IL-13 Ab in human doseranging studies.

Serum concentrations of IMA-638 or IMA-026 were determined by ELISA.

Kasaian, M. T., Raible, D., Marquette, K., Cook, T. A., Zhou, S., Tan, X. Y., & Tchistiakova, L. (2011). IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2. The Journal of Immunology, 187(1), 561-569.

Figure 5 Anti–IL-13 Abs differentially affect IL-13 internalization.

Assays were developed to detect IL-13 in the presence or absence of anti-IL-13 Abs: IMA-026. The extracellular medium was collected and assayed for IL-13 using ELISAs developed to detect the cytokine in the presence of anti–IL-13 Ab.

Kasaian, M. T., Raible, D., Marquette, K., Cook, T. A., Zhou, S., Tan, X. Y., & Tchistiakova, L. (2011). IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2. The Journal of Immunology, 187(1), 561-569.

Figure 6 Surface plasmon resonance (Biacore) analysis of human or sheep IL-13 binding to immobilized sIL-13R or IMA-638.

Human IL-13 binding to IMA-638.

Kasaian, M. T., Donaldson, D. D., Tchistiakova, L., Marquette, K., Tan, X. Y., Ahmed, A., ... & Barry, A. B. (2007). Efficacy of IL-13 neutralization in a sheep model of experimental asthma. American journal of respiratory cell and molecular biology, 36(3), 368-376.