Recombinant Anti-IL13 Eliminating Antibody, pH-Sensitive (VS-0625-YC165)

Name: Recombinant Anti-IL13 Eliminating Antibody, pH-Sensitive (VS-0625-YC165)
SKU: VS-0625-YC165
Rating: 5 (1 reviews)

CAT#: VS-0625-YC165

The anti-IL13 eliminating antibody is an engineered pH-sensitive antibody against human IL13. IL13 is a cytokine moderating inflammatory responses in conjunction with other interleukins. The antibody has a novel IL13-sweeping activity in vivo, which selectively eliminatesthe soluble IL13 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg

RNA Expression Figure 4 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13

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Specifications

Host Species
Human

Type
Human IgG4 lambda

Specificity
Human IL13

Species Reactivity
Human

Applications
Antigen-Sweeping In Vivo.

Product Property

Purification
Protein A/G purified

Purity
>95%

Format
Liquid

Buffer
PBS only

Preservative
None

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
IL13; interleukin 13; interleukin-13; allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; MGC116786; MGC116788; MGC116789; P600; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13;

Gene ID
3596

UniProt ID
P35225

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Related Diseases

Asthma

Inflammatory Bowel Diseases

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0625-YC165.pdf

MSDS

MSDS - VS-0625-YC165.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
TAB-218	Anti-Human IL13 Recombinant Antibody (Tralokinumab)	ELISA, FC, IP, FuncS, IF, Neut, ICC	IgG4 - lambda
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TAB-069ZJ-F(E)	Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-069ZJ-F(E))	ELISA, Neut, FC	Human Fab
TAB-070ZJ-F(E)	Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-070ZJ-F(E))	ELISA, Neut, FC	Human Fab

CAT	Product Name	Application	Type
PABL-603	Human Anti-IL13 Recombinant Antibody (clone C836)	Neut	Chimeric (mouse/human) IgG
PABL-605	Human Anti-IL13 Recombinant Antibody (clone H2L6)	ELISA	Humanized IgG
PABL-606	Human Anti-IL13 Recombinant Antibody (clone X836)	WB, ELISA, FuncS	Chimeric (mouse/human) IgG
HPAB-0226CQ	Human Anti-IL13 Recombinant Antibody (HPAB-0226CQ)	ELISA, Neut, FC, FuncS	Human IgG2
HPAB-0227CQ	Human Anti-IL13 Recombinant Antibody (HPAB-0227CQ)	ELISA, Neut, FC, FuncS	Human IgG2

CAT	Product Name	Application	Type
PFBL-598	Human Anti-IL13 Recombinant Antibody (clone C836); Fab Fragment	Neut	Chimeric (mouse/human) Fab
PFBL-600	Human Anti-IL13 Recombinant Antibody (clone H2L6); Fab Fragment	ELISA	Humanized Fab
PFBL-601	Human Anti-IL13 Recombinant Antibody (clone X836); Fab Fragment	WB, ELISA, FuncS	Chimeric (mouse/human) Fab
PFBW-170	Human Anti-IL13 Recombinant Antibody (clone CNTO607); Fab Fragment	ELISA, WB, Neut	Human Fab
HPAB-0355-WJ-F(E)	Human Anti-IL13 Recombinant Antibody Fab Fragment (HPAB-0355-WJ-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application	Type
PSBL-598	Mouse Anti-IL13 Recombinant Antibody (clone C836); scFv Fragment	Neut	Mouse scFv
PSBL-600	Human Anti-IL13 Recombinant Antibody (clone H2L6); scFv Fragment	ELISA	Humanized scFv
PSBL-601	Mouse Anti-IL13 Recombinant Antibody (clone X836); scFv Fragment	WB, ELISA, FuncS	Mouse scFv
PSBW-170	Human Anti-IL13 Recombinant Antibody (clone CNTO607); scFv Fragment	ELISA, WB, Neut	Human scFv
HPAB-0226CQ-S(P)	Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0226CQ-S(P))	ELISA, Neut, FC, FuncS	Human scFv

CAT	Product Name	Application	Type
TAB-022ZJ	Anti-Human IL-13 Recombinant Antibody (C836)	ELISA
TAB-023ZJ	Mouse Anti-IL13 Recombinant Antibody (TAB-023ZJ)	ELISA, Block	Mouse IgG
TAB-022ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (C836)	ELISA
TAB-023ZJ-S(P)	Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-023ZJ-S(P))	ELISA, Block	Mouse scFv
TAB-022ZJ-F(E)	Anti-Human IL-13 Recombinant Antibody Fab Fragment (C836)	ELISA

CAT	Product Name	Application	Type
TAB-043ZJ	Anti-Human IL-13 Recombinant Antibody (Lc6Hc2)	ELISA	Humanized antibody
TAB-044ZJ	Human Anti-IL13 Recombinant Antibody (TAB-044ZJ)	ELISA, Neut	Humanized IgG
TAB-045ZJ	Human Anti-IL13 Recombinant Antibody (TAB-045ZJ)	ELISA, Block	Humanized IgG
TAB-046ZJ	Human Anti-IL13 Recombinant Antibody (TAB-046ZJ)	ELISA, Block	Humanized IgG
TAB-043ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (Lc6Hc2)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
TAB-094ZJ	Anti-Human IL-13 Recombinant Antibody (167)	ELISA	Chimeric antibody (mouse/human)
TAB-094ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (167)	ELISA	Chimeric antibody (mouse/human)
TAB-094ZJ-F(E)	Anti-Human IL-13 Recombinant Antibody Fab Fragment (167)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
NEUT-1171CQ	Mouse Anti-IL13 Recombinant Antibody (clone B-B13)	ELISA, ELISPOT, Neut	Mouse IgG1
NEUT-1172CQ	Mouse Anti-IL13 Recombinant Antibody (clone 10X28)	Neut, WB	Mouse IgG1
NEUT-1173CQ	Mouse Anti-IL13 Recombinant Antibody (NEUT-1173CQ)	Neut	Mouse IgG2b
NEUT-1174CQ	Mouse Anti-IL13 Recombinant Antibody (clone 32116.11)	ELISA, Neut, WB	Mouse IgG1
NEUT-1175CQ	Rat Anti-IL13 Recombinant Antibody (clone 5A2)	Neut	Rat IgG1

CAT	Product Name	Application	Type
MOR-1790	Rabbit Anti-IL13 Recombinant Antibody (clone DS1790AB)	WB, ICC, FC, IP	Rabbit IgG
MOR-4610	Rabbit Anti-IL13 Recombinant Antibody (clone TH123DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
AFC-TAB-H05	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H05)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-017ML	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-017ML)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody
AFC-TAB-219	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-219)	ELISA, Neut, IF, IP, FC, FuncS	ADCC enhanced antibody
AFC-TAB-218	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-218)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0225-XY129	CytoStream™ Rat Anti-IL13 Recombinant Antibody (clone JES10-5A2)	ELISA, FC, Neut, IHC, WB	Rat IgG1

CAT	Product Name	Application	Type
VS-0425-FY124	Human Anti-IL13 (clone IMA-638) scFv-Fc Chimera	ELISA, FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0525-XY3484	Anti-IL13 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC216	Recombinant Anti-IL13 Biparatopic Antibody, Tandem scFv (Anrukinzumab x Clone IMA-026)	ELISA	Tandem scFv

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