Anti-IL2 Antibody-Cytokine Fusion Protein, scfv (JES6-1)-IL2 (CAT#: VS-0624-FY75)
JES6-1 is a rat monoclonal antibody that can bind to IL-2 to form a complex that enhances sensitivity to LPS (lipopolysaccharide). This product is a anti-IL2 (clone JES6-1) scfv-mouse IL2 immunocytokine. mIL-2 was strategically positioned N-terminally to the VL domain of the light chain construct. The IL-2-JES6-1 immunocytokine has been shown to demonstrate diminished activation of IL-2Rαᴴⁱᵍʰ cells. The IL-2 cytokine was fused to the JES6-1 antibody to form a single-dose fusion protein that retained the exchange mechanism of IL-2 and selectively stimulated the expansion of Treg cells.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
Figure 2 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
Figure 3 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
Figure 4 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
Specifications
- Target
- IL2
- Molecule Class
- scfv-IL2
- Species Reactivity
- Mouse
- Expression Host
- 293F
- Clone
- JES6-1
- Related Disease
- Breast Cancer and Diphtheria
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activity of white blood cells (leukocytes, usually lymphocytes) responsible for immunity.
- Cytokine 1 Species
- Mouse
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
- Alternative Names
- Interleukin 2
- Gene ID
- 3558
- UniProt ID
- P60568
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-093 | Recombinant Anti-Mouse Il2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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