Anti-IL2 Antibody-Cytokine Fusion Protein, scfv (JES6-1)-IL2
CAT#: VS-0624-FY75
JES6-1 is a rat monoclonal antibody that can bind to IL-2 to form a complex that enhances sensitivity to LPS (lipopolysaccharide). This product is a anti-IL2 (clone JES6-1) scfv-mouse IL2 immunocytokine. mIL-2 was strategically positioned N-terminally to the VL domain of the light chain construct. The IL-2-JES6-1 immunocytokine has been shown to demonstrate diminished activation of IL-2Rαᴴⁱᵍʰ cells. The IL-2 cytokine was fused to the JES6-1 antibody to form a single-dose fusion protein that retained the exchange mechanism of IL-2 and selectively stimulated the expansion of Treg cells.
Gene Expression
Normal Tissue
Figure 1 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
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Specifications
- Target
- IL2
- Molecule Class
- scfv-IL2
- Species Reactivity
- Mouse
- Expression Host
- 293F
- Clone
- JES6-1
- Related Disease
- Breast Cancer and Diphtheria
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activity of white blood cells (leukocytes, usually lymphocytes) responsible for immunity.
- Cytokine 1 Species
- Mouse
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
- Alternative Names
- Interleukin 2
- Gene ID
- 3558
- UniProt ID
- P60568
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Related Diseases
Autoimmune Thyroid Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
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Datasheet
MSDS
COA
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