Human Anti-IL20 Recombinant Antibody (clone 5B7) (CAT#: HPAB-0724-CN)

This is an anti-human IL20 monoclonal antibody that can reduce IL20 mediated activation of both IL20R1/IL20R2 and IL22R1/IL20R2 receptor complexes. The antibody 5B7 can be used for treating various diseases and disorders, including autoimmune or inflammatory diseases or disorders.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
WB

Figure 1 Anti-IL-20 mAb 7E improved motor function and sensory function in SCI rats.

Figure 1 Anti-IL-20 mAb 7E improved motor function and sensory function in SCI rats.

Data from one representative experiment of three independent experiments is shown.

Lee, J. S., Hsu, Y. H., Chiu, Y. S., Jou, I. M., & Chang, M. S. (2020). Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats. Journal of Neuroinflammation, 17, 1-12.

IHC

Figure 2 IL-20 promoted astrocyte activation in HA cell line.

Figure 2 IL-20 promoted astrocyte activation in HA cell line.

Data are expressed as mean ± SD and are representative of three independent experiments performed in triplicate.

Lee, J. S., Hsu, Y. H., Chiu, Y. S., Jou, I. M., & Chang, M. S. (2020). Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats. Journal of Neuroinflammation, 17, 1-12.

FC

Figure 3 OC-3 and OEC-M1 cells were treated with IL-20 for the indicated concentrations in serum-free medium for 30 minutes, and ROS generation was measured using flow cytometry.

Figure 3 OC-3 and OEC-M1 cells were treated with IL-20 for the indicated concentrations in serum-free medium for 30 minutes, and ROS generation was measured using flow cytometry.

Data from one representative experiment of three independent experiments is shown.

Hsu, Y. H., Wei, C. C., Shieh, D. B., Chan, C. H., & Chang, M. S. (2012). Anti–IL-20 Monoclonal Antibody Alleviates Inflammation in Oral Cancer and Suppresses Tumor Growth. Molecular Cancer Research, 10(11), 1430-1439.


Specifications

  • Immunogen
  • Human IL-20
  • Host Species
  • Human
  • Type
  • Human IgG4, κ
  • Specificity
  • Human IL20
  • Species Reactivity
  • Human, Cynomolgus, Mouse
  • Clone
  • 5B7
  • Applications
  • WB, FC, IHC
  • Related Disease
  • Autoimmune, Inflammatory diseases

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The IL20 antibody has been reported in applications of Western Blot, Immunohistochemistry, Flow Cytometry.

Target

  • Alternative Names
  • Interleukin 20

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 5B7"

See other products for "IL20"

Human Antibody

CAT Product Name Application Type
TAB-H34 Anti-Human IL20 Recombinant Antibody (Fletikumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG4 - kappa
TAB-561LC Anti-human IL20 Recombinant Antibody (20A10) (TAB-561LC) ELISA, Neut, SPR Human antibody
TAB-562LC Anti-human IL20 Recombinant Antibody (2A11) (TAB-562LC) ELISA, Neut, SPR Human antibody
TAB-563LC Anti-human IL20 Recombinant Antibody (7D1) (TAB-563LC) ELISA, Neut, SPR Human antibody
TAB-564LC Anti-human IL20 Recombinant Antibody (6E11) (TAB-564LC) ELISA, Neut Human antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1324CQ Rat Anti-Il20 Recombinant Antibody (clone CBL626) Neut Rat IgG2b

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4256 Rabbit Anti-IL20 Recombinant Antibody (clone SI336DS) ELISA Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H34 Afuco™ Anti-IL20 ADCC Recombinant Antibody (Fletikumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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