This is an anti-human IL20 monoclonal antibody that can reduce IL20 mediated activation of both IL20R1/IL20R2 and IL22R1/IL20R2 receptor complexes. 15D2 inhibited cynomolgus IL20-induced as well as mouse IL20-induced proliferation of the BaF-3(hIL20R) cells, while hIL19 or hIL24-induced proliferation of BaF-3(hIL20R) was not inhibited by 15D2.
Figure 1 IL-20 induction of tumor necrosis factor α (TNFα) in SFs from rats with CIA was determined at the indicated time points.
Functions of interleukin-20 (IL-20) in synovial fibroblasts (SFs).
Hsu, Y. H., & Chang, M. S. (2010). Interleukin‐20 antibody is a potential therapeutic agent for experimental arthritis. Arthritis & Rheumatism, 62(11), 3311-3321.
Figure 2 Induction of RANKL was measured in untreated MC3T3-E1 cells and in MC3T3-E1 cells treated for 16 hours with IL-20 (200 ng/ml), IL-17 (50 ng/ml), or both IL-20 and IL-27.
Cells were stained with phycoerythrin-conjugated anti-RANKL antibody and analyzed by flow cytometry. Values are the mean and SD.
Hsu, Y. H., & Chang, M. S. (2010). Interleukin‐20 antibody is a potential therapeutic agent for experimental arthritis. Arthritis & Rheumatism, 62(11), 3311-3321.
Figure 3 Immunohistochemical stain of skin section with monoclonal antibodies against IL-20.
Strong expression of IL-20 in some perivascular mononuclear cells (could be dendritic cells).
Wei, C. C., Chen, W. Y., Wang, Y. C., Chen, P. J., Lee, J. Y. Y., Wong, T. W., ... & Lin, Y. C. (2005). Detection of IL-20 and its receptors on psoriatic skin. Clinical Immunology, 117(1), 65-72.
Figure 4 IL-20 level in the blood of psoriasis patients and healthy control.
Horizontal bars show mean values of IL-20 concentration in serum of healthy controls (215 ng/ml) and psoriasis patients (67.2 ng/ml).
Wei, C. C., Chen, W. Y., Wang, Y. C., Chen, P. J., Lee, J. Y. Y., Wong, T. W., ... & Lin, Y. C. (2005). Detection of IL-20 and its receptors on psoriatic skin. Clinical Immunology, 117(1), 65-72.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0009CL | Human Anti-IL20 Recombinant Antibody (TAB-0009CL) | Inhib, IB, FC, RIA | Humanized Antibody |
TAB-0009CL-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (TAB-0009CL-F(E)) | Inhib, ELISA, SPR | Humanized Fab |
TAB-565LC | Anti-human IL20 Recombinant Antibody (FLB5M5) (TAB-565LC) | ELISA, Inhib, FuncS | Humanized antibody |
TAB-565LC-S(P) | Anti-human IL20 scFv Fragment (FLB5M5) | ELISA | Humanized antibody |
TAB-565LC-F(E) | Anti-human IL20 Fab Fragment (FLB5M5) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-560LC | Rat Anti-IL20 Recombinant Antibody (TAB-560LC) | ELISA | Rat IgG |
TAB-560LC-S(P) | Rat Anti-IL20 Recombinant Antibody; scFv Fragment (TAB-560LC-S(P)) | ELISA | Rat scFv |
TAB-560LC-F(E) | Rat Anti-IL20 Recombinant Antibody; Fab Fragment (TAB-560LC-F(E)) | ELISA | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-561LC-S(P) | Anti-human IL20 scFv Fragment (20A10) | ELISA | Human antibody |
TAB-561LC-F(E) | Anti-human IL20 Fab Fragment (20A10) | ELISA | Human antibody |
TAB-562LC-F(E) | Anti-human IL20 Fab Fragment (2A11) | ELISA | Human antibody |
TAB-563LC-F(E) | Anti-human IL20 Fab Fragment (7D1) | ELISA | Human antibody |
TAB-564LC-F(E) | Anti-human IL20 Fab Fragment (6E11) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0963CT | Recombinant Mouse anti-Human IL20 Monoclonal antibody (EML1475) | WB | |
HPAB-0008-LS | Human Anti-IL20 Recombinant Antibody (HPAB-0008-LS) | Inhib | Humanized lgG |
HPAB-0009-LS | Human Anti-IL20 Recombinant Antibody (HPAB-0009-LS) | Inhib | Humanized lgG |
HPAB-0724-CN | Human Anti-IL20 Recombinant Antibody (clone 5B7) | WB, FC, IHC | Human IgG4, κ |
HPAB-0069-WJ | Human Anti-IL20 Recombinant Antibody (HPAB-0069-WJ) | WB, FC, IHC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1324CQ | Rat Anti-Il20 Recombinant Antibody (clone CBL626) | Neut | Rat IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4256 | Rabbit Anti-IL20 Recombinant Antibody (clone SI336DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0008-LS-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (HPAB-0008-LS-F(E)) | Inhib | Humanized Fab |
HPAB-0009-LS-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (HPAB-0009-LS-F(E)) | Inhib | Humanized Fab |
HPAB-0723-CN-F(E) | Human Anti-IL20 Recombinant Antibody (clone 15D2); Fab Fragment | WB, ELISA, Neut | Human Fab |
HPAB-0724-CN-F(E) | Human Anti-IL20 Recombinant Antibody (clone 5B7); Fab Fragment | WB, ELISA, Neut | Human Fab |
HPAB-0069-WJ-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (HPAB-0069-WJ-F(E)) | IHC, ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0008-LS-S(P) | Human Anti-IL20 Recombinant Antibody; scFv Fragment (HPAB-0008-LS-S(P)) | Inhib | Humanized scFv |
HPAB-0009-LS-S(P) | Human Anti-IL20 Recombinant Antibody; scFv Fragment (HPAB-0009-LS-S(P)) | Inhib | Humanized scFv |
HPAB-0723-CN-S(P) | Human Anti-IL20 Recombinant Antibody (clone 15D2); scFv Fragment | WB, ELISA, Neut | Human scFv |
HPAB-0724-CN-S(P) | Human Anti-IL20 Recombinant Antibody (clone 5B7); scFv Fragment | WB, ELISA, Neut | Human scFv |
HPAB-0069-WJ-S(P) | Human Anti-IL20 Recombinant Antibody; scFv Fragment (HPAB-0069-WJ-S(P)) | IHC, ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H34 | Afuco™ Anti-IL20 ADCC Recombinant Antibody (Fletikumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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