Mouse Anti-IL21 Recombinant Antibody (clone 3E11) (CAT#: HPAB-0657-CN)
This is a monoclonal antibody which binds and neutralizes the activity of IL-21 in particular human IL-21. The mAb 3E11 can be used to treat certain IL-21 responsive disorders, for example, certain inflammatory bowel diseases or psoriasis.
Specific Inquiry
FC
Figure 1 IL-21 induces plasma cell differentiation.
Data are representative of results from three similar experiments.
Ettinger, R., Sims, G. P., Fairhurst, A. M., Robbins, R., da Silva, Y. S., Spolski, R., ... & Lipsky, P. E. (2005). IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. The Journal of Immunology, 175(12), 7867-7879.
WB
Figure 2 IL-21 alters the antiapoptotic profile induced by CD40L by downregulating Bcl-XL and induces proliferation through Jak-STAT3.
CLL cells, cultured with CD40L-expressing fibroblasts in the absence or presence of IL-21 for 16 hours.
Pascutti, M. F., Jak, M., Tromp, J. M., Derks, I. A., Remmerswaal, E. B., Thijssen, R., ... & van Lier, R. A. (2013). IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. Blood, The Journal of the American Society of Hematology, 122(17), 3010-3019.
IHC
Figure 3 IL-21 expression in lymph nodes from CLL patients.
IL-21 expression was analyzed in 2 paraffin-embedded CLL LN samples by IHC.
Pascutti, M. F., Jak, M., Tromp, J. M., Derks, I. A., Remmerswaal, E. B., Thijssen, R., ... & van Lier, R. A. (2013). IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. Blood, The Journal of the American Society of Hematology, 122(17), 3010-3019.
Specifications
- Immunogen
- Peptide GM2 comprises the following sequence NVS IKK LKR KPP STN corresponding to amino acids 97-1 11 of human IL-21 sequence
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human IL21
- Species Reactivity
- Human
- Clone
- 3E11
- Applications
- WB, FC, IHC
- Related Disease
- Chronic inflammatory bowel diseases (IBD), celiac disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IL21 antibody has been reported in applications of Western Blot, Immunohistochemistry, Flow Cytometry.
Target
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1131z | Mouse Anti-IL21 Recombinant Antibody (clone 38D2) | WB, ELISA, FC, ICC, IHC, IP | Mouse IgG2a |
| HPAB-0315-CN | Human Anti-IL21 Recombinant Antibody (HPAB-0315-CN) | ELISA, Neut | Humanized IgG1 |
| HPAB-0287-FY | Human Anti-IL21 Recombinant Antibody (clone mAb14) | Inhib, Neut | Human IgG4, κ |
| HPAB-M0538-YC | Mouse Anti-IL21 Recombinant Antibody (HPAB-M0538-YC) | ELISA | Mouse IgG |
| VS3-FY753 | Recombinant Mouse Anti-IL21 Antibody (clone 7D8E4) | ELISA, IHC, FC | Mouse IgG1 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-570LC | Mouse Anti-IL21 Recombinant Antibody (TAB-570LC) | ELISA, FC, Inhib | Mouse IgG |
| TAB-571LC | Mouse Anti-IL21 Recombinant Antibody (TAB-571LC) | ELISA, FC, Inhib | Mouse IgG |
| TAB-575LC | Mouse Anti-IL21 Recombinant Antibody (TAB-575LC) | ELISA, FC | Mouse IgG |
| TAB-570LC-S(P) | Mouse Anti-IL21 Recombinant Antibody; scFv Fragment (TAB-570LC-S(P)) | ELISA | Mouse scFv |
| TAB-571LC-S(P) | Mouse Anti-IL21 Recombinant Antibody; scFv Fragment (TAB-571LC-S(P)) | ELISA | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-572LC | Human Anti-IL21 Recombinant Antibody (TAB-572LC) | Inhib | Humanized IgG |
| TAB-573LC | Human Anti-IL21 Recombinant Antibody (TAB-573LC) | Inhib | Humanized IgG |
| TAB-574LC | Human Anti-IL21 Recombinant Antibody (TAB-574LC) | Inhib | Humanized IgG |
| TAB-576LC | Human Anti-IL21 Recombinant Antibody (TAB-576LC) | ELISA, FC, Neut, FuncS | Humanized antibody |
| TAB-572LC-S(P) | Human Anti-IL21 Recombinant Antibody; scFv Fragment (TAB-572LC-S(P)) | ELISA | Humanized scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-577LC-F(E) | Human Anti-IL21 Recombinant Antibody; Fab Fragment (TAB-577LC-F(E)) | ELISA, FC | Human Fab |
| TAB-578LC-F(E) | Human Anti-IL21 Recombinant Antibody; Fab Fragment (TAB-578LC-F(E)) | ELISA, WB, FC | Human Fab |
| TAB-579LC-F(E) | Human Anti-IL21 Recombinant Antibody; Fab Fragment (TAB-579LC-F(E)) | ELISA, WB, FC | Human Fab |
| TAB-580LC-F(E) | Human Anti-IL21 Recombinant Antibody; Fab Fragment (TAB-580LC-F(E)) | ELISA, WB, FC | Human Fab |
| TAB-581LC-F(E) | Human Anti-IL21 Recombinant Antibody; Fab Fragment (TAB-581LC-F(E)) | ELISA, WB, FC | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0291MZ | Chicken Anti-Interleukin-21 Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1325CQ | Mouse Anti-IL21 Recombinant Antibody (clone MT216G/21.3m) | Neut | Mouse IgG1 |
| NEUT-1326CQ | Rat Anti-Il21 Recombinant Antibody (clone FFA21) | FuncS, Neut, IF | Rat IgG2a, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1802 | Rabbit Anti-IL21 Recombinant Antibody (clone DS1802AB) | WB | Rabbit IgG |
| MOR-4260 | Rabbit Anti-IL21 Recombinant Antibody (clone SI340DS) | ELISA | Rabbit IgG |
| MOR-4613 | Rabbit Anti-IL21 Recombinant Antibody (clone TH126DS) | ELISA | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0315-CN-F(E) | Human Anti-IL21 Recombinant Antibody; Fab Fragment (HPAB-0315-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0287-FY-F(E) | Human Anti-IL21 Recombinant Antibody (clone mAb14); Fab Fragment | Inhib, Neut | Human Fab, κ |
| HPAB-0130-WJ-F(E) | Human Anti-IL21 Recombinant Antibody; Fab Fragment (HPAB-0130-WJ-F(E)) | ELISA | Humanized Fab |
| FAMAB-0210WJ-F(E) | Mouse Anti-IL21 Recombinant Antibody (clone 9H10); Fab Fragment | ELISA, WB | Mouse Fab |
| FAMAB-0211WJ-F(E) | Mouse Anti-IL21 Recombinant Antibody (clone 8B6); Fab Fragment | ELISA, WB | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0538-YC-S(P) | Mouse Anti-IL21 Recombinant Antibody; scFv Fragment (HPAB-M0538-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-M0539-YC-S(P) | Mouse Anti-IL21 Recombinant Antibody; scFv Fragment (HPAB-M0539-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-M0540-YC-S(P) | Mouse Anti-IL21 Recombinant Antibody; scFv Fragment (HPAB-M0540-YC-S(P)) | ELISA | Mouse scFv |
| FAMAB-0210WJ-S(P) | Mouse Anti-IL21 Recombinant Antibody (clone 9H10); scFv Fragment | ELISA, WB | Mouse scFv |
| FAMAB-0211WJ-S(P) | Mouse Anti-IL21 Recombinant Antibody (clone 8B6); scFv Fragment | ELISA, WB | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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