Human Anti-Il21r Recombinant Antibody (clone 18A5) (CAT#: HPAB-0668-CN)
This is a monoclonal antibody which specifically binds to the human interleukin-21 receptor (IL-21R). This mAb can act as the antagonist of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. This product has been detected by Flow cytometry and Immunohistochemistry.
Specific Inquiry
FC
Figure 1 IL-21R expression was determined by flow cytometry on peripheral blood mononuclear cells.
The percentage of IL-21R+ cells was assayed in the CD4+ lymphocytes.
Van Der Fits, L., Out-Luiting, J. J., Van Leeuwen, M. A., Samsom, J. N., Willemze, R., Tensen, C. P., & Vermeer, M. H. (2012). Autocrine IL-21 stimulation is involved in the maintenance of constitutive STAT3 activation in Sezary syndrome. Journal of investigative dermatology, 132(2), 440-447.
IHC
Figure 2 IL-21-specific receptor (IL-21R) expression in Sézary syndrome (SS) cells in skin biopsies.
Representative examples are shown.
Van Der Fits, L., Out-Luiting, J. J., Van Leeuwen, M. A., Samsom, J. N., Willemze, R., Tensen, C. P., & Vermeer, M. H. (2012). Autocrine IL-21 stimulation is involved in the maintenance of constitutive STAT3 activation in Sezary syndrome. Journal of investigative dermatology, 132(2), 440-447.
Specifications
- Host Species
- Human
- Derivation
- scFv phage display library
- Type
- Human IgG1
- Specificity
- Human Il21r
- Species Reactivity
- Human, Mouse
- Clone
- 18A5
- Applications
- FC, IHC
- Related Disease
- Inflammatory disorders, autoimmune diseases, allergies, transplant rejection, hyperproliferative disorders of the blood, other immune system disorders
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IL21R antibody has been reported in applications of Immunohistochemistry, Flow Cytometry.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
Mouse Antibody
Human Antibody
Blocking Antibody
Rabbit Monoclonal Antibody
scFv Fragment Antibody
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1347z | Mouse Anti-IL21R Recombinant Antibody (clone 44B3) | WB, IP, IF, ELISA | Mouse IgG2a, κ |
| HPAB-0669-CN | Human Anti-IL21R Recombinant Antibody (clone ABS) | ELISA, FC, Neut | Human IgG |
| HPAB-0247CQ | Human Anti-IL21R Recombinant Antibody (clone 19F5) | Neut, WB, ELISA, FC, IHC | Human IgG1 |
| HPAB-AP685-YC | Human Anti-IL21R Recombinant Antibody (clone C2) | ELISA | Human IgG |
| FAMAB-1203CQ | Human Anti-IL21R Recombinant Antibody (clone ATR-107) | Inhib, FC, WB | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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