Afuco™ Anti-IL23A ADCC Recombinant Antibody (Risankizumab), ADCC Enhanced (CAT#: AFC-TAB-620LC)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody Risankizumab is a humanized monoclonal antibody that specifically binds to human IL-23A and can be potentially used in the treatment of Crohn's disease, psoriasis, psoriatic arthritis and asthma.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/if_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells in and outside germinal center.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_8_selected.jpg
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells in and outside germinal center.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_8_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/60_H7_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/60_H7_1_blue_red_green.jpg
Figure 4 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_9_3.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_9_3.jpg
Figure 5 Testis
(Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_6.jpg
(Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_6.jpg
Figure 6 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_8_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_8_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110944-IL23A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110944-IL23A
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Risankizumab
- Applications
- ELISA
- Conjugate
- Unconjugated
- Related Disease
- Crohn's disease, psoriasis, psoriatic arthritis and asthma
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; interleukin-23 subunit alpha
- Gene ID
- 51561
- UniProt ID
- Q9NPF7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone Risankizumab"
See other products for "IL23A"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1953-VHH | Recombinant Anti-human IL23A VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| TAB-005LC-VHH | Anti-human IL23A Recombinant Antibody (119A3) (TAB-005LC-VHH) | ELISA | Single domain antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605LC | Anti-human IL23A Recombinant Antibody (FM303) (TAB-605LC) | ELISA | Humanized antibody |
| TAB-608LC | Anti-human IL23A Recombinant Antibody (21-4) (TAB-608LC) | ELISA | Humanized antibody |
| TAB-609LC | Anti-human IL23A Recombinant Antibody (8-22) (TAB-609LC) | ELISA | Humanized antibody |
| TAB-610LC | Anti-human IL23A Recombinant Antibody (6-22) (TAB-610LC) | ELISA | Humanized antibody |
| TAB-611LC | Anti-human IL23A Recombinant Antibody (1-4) (TAB-611LC) | ELISA | Humanized antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-607LC | Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) | ELISA, Neut, FuncS | Chimeric antibody (rat/human) |
| TAB-607LC-S(P) | Anti-human IL23A scFv Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
| TAB-607LC-F(E) | Anti-human IL23A Fab Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-614LC | Anti-human IL23A Recombinant Antibody (8C9) (TAB-614LC) | ELISA, Inhib | |
| TAB-614LC-S(P) | Anti-human IL23A scFv Fragment (8C9) | ELISA, FC | |
| TAB-615LC-S(P) | Anti-human IL23A scFv Fragment (2H6) | ELISA, FC | |
| TAB-621LC-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (TAB-621LC-S(P)) | ELISA, WB | Mouse scFv |
| TAB-606LC-F(E) | Anti-human IL23A Fab Fragment (E11E7) | ELISA |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-622LC | Human Anti-IL23A Recombinant Antibody (TAB-622LC) | ELISA | Human antibody |
| TAB-613LC-S(P) | Anti-human IL23A scFv Fragment (ST883/885) | ELISA | Human antibody |
| TAB-622LC-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (TAB-622LC-S(P)) | ELISA | Human scFv |
| TAB-613LC-F(E) | Anti-human IL23A Fab Fragment (ST883/885) | ELISA | Human antibody |
| TAB-622LC-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (TAB-622LC-F(E)) | ELISA | Human Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1335CQ | Mouse Anti-IL23A Recombinant Antibody (clone HNU2319) | FuncS, Neut | Mouse IgG1, κ |
| NEUT-1336CQ | Rabbit Anti-IL23A Recombinant Antibody (VMC198) | WB, Neut | Rabbit IgG2b |
| NEUT-1337CQ | Human Anti-IL23A Recombinant Antibody (clone CBL1018) | Neut | Human IgG1, κ |
| NEUT-1338CQ | Mouse Anti-IL23A Recombinant Antibody (clone M066) | Neut | Mouse IgG1 |
| NEUT-1339CQ | Mouse Anti-Il23a Recombinant Antibody (clone CBL1028) | Neut | Mouse IgG2b, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4335 | Rabbit Anti-IL23A Recombinant Antibody (clone SI424DS) | ELISA | Rabbit IgG |
| MOR-4615 | Rabbit Anti-IL23A Recombinant Antibody (clone TH128DS) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-655-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody (clone 8C92H6); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0860-FY-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0860-FY-F(E)) | Inhib | Mouse Fab |
| HPAB-0861-FY-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0861-FY-F(E)) | Inhib | Mouse Fab |
| HPAB-1560-FY-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-1560-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-1561-FY-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-1561-FY-F(E)) | ELISA | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-875 | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Tildrakizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-008ML | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Brazikumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0860-FY | Mouse Anti-IL23A Recombinant Antibody (HPAB-0860-FY) | WB | Mouse IgG |
| HPAB-0861-FY | Mouse Anti-IL23A Recombinant Antibody (HPAB-0861-FY) | Inhib | Mouse IgG |
| HPAB-0865-FY | Mouse Anti-IL23A Recombinant Antibody (HPAB-0865-FY) | ELISA | Mouse IgG |
| HPAB-0866-FY | Mouse Anti-IL23A Recombinant Antibody (HPAB-0866-FY) | ELISA | Mouse IgG |
| HPAB-0867-FY | Mouse Anti-IL23A Recombinant Antibody (HPAB-0867-FY) | ELISA | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0860-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0860-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-0861-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0861-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-0865-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0865-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0866-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0866-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0867-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0867-FY-S(P)) | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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