Anti-IL25 (clone W24V106) Recombinant Antibody Coupled Liposome (VS-1024-FY108)
CAT#: VS-1024-FY108
The anti-IL-25 antibody-conjugated liposomes have demonstrated a remarkable ability to selectively target and induce cytotoxic effects in glioma cells, showcasing their promise as a therapeutic option for this aggressive form of brain tumor. By leveraging the unique properties of liposomes, these conjugated agents can encapsulate therapeutic drugs and deliver them directly to the tumor site, thereby minimizing systemic side effects and maximizing treatment efficacy. This targeted delivery approach not only improves the effectiveness of the therapy but also opens up new avenues for personalized medicine in the management of glioma, offering hope for improved patient outcomes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human testis
Immunohistochemical staining of human testis shows moderate positivity in cells in seminiferus ducts and strong positivity in leydig cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24864/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24864/60237_B_9_5.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24864/60237_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24864/60237_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24864/60237_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24864/60237_A_8_8.jpg
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V106
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody designed to selectively bind to human interleukin-25 (IL-25). Interleukin-25 is a cytokine that plays a crucial role in the immune response, particularly in promoting the differentiation of T-helper 2 (Th2) cells and the subsequent production of other cytokines involved in allergic and inflammatory responses.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IL25
- Introduction
- The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants.
- Alternative Names
- IL17E; interleukin-25; interleukin-17E
- Full Name
- Interleukin 25
- Gene ID
- 64806
- UniProt ID
- Q9H293
- Sequence Similarities
- Belongs to the IL-17 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn136 ( NX_Q9H293 [NX_Q9H293-1] )
Modification sites at PhosphoSitePlus ( Q9H293 )
Glycosylation from GlyGen (Q9H293) 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_073626.1; NP_758525.1
- Function
- Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production.
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Datasheet
MSDS
COA
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|---|---|---|---|
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| MHH-565-S(P) | Recombinant Human Anti-human IL25 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| TAB-635LC-S(P) | Human Anti-IL25 Recombinant Antibody; scFv Fragment (TAB-635LC-S(P)) | ELISA, Neut, FuncS | Human scFv |
| HPAB-M0541-YC-S(P) | Mouse Anti-IL25 Recombinant Antibody; scFv Fragment (HPAB-M0541-YC-S(P)) | Neut | Mouse scFv |
| HPAB-M0542-YC-S(P) | Mouse Anti-IL25 Recombinant Antibody; scFv Fragment (HPAB-M0542-YC-S(P)) | Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-631LC | Mouse Anti-IL25 Recombinant Antibody (TAB-631LC) | ELISA | Mouse IgGκ |
| TAB-631LC-S(P) | Mouse Anti-IL25 Recombinant Antibody; scFv Fragment (TAB-631LC-S(P)) | ELISA | Mouse scFv |
| TAB-631LC-F(E) | Mouse Anti-IL25 Recombinant Antibody; Fab Fragment (TAB-631LC-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-633LC | Human Anti-IL25 Recombinant Antibody (TAB-633LC) | ELISA, FC | Human IgG4 |
| TAB-633LC-S(P) | Human Anti-IL25 Recombinant Antibody (TAB-633LC-S(P)); scFv Fragment | ELISA, FC | Human scFv |
| TAB-633LC-F(E) | Human Anti-IL25 Recombinant Antibody (TAB-633LC-F(E)); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-634LC | Mouse Anti-IL25 Recombinant Antibody (TAB-634LC) | ELISA, FC | Mouse IgG2a |
| TAB-632LC-S(P) | Mouse Anti-IL25 Recombinant Antibody (TAB-632LC-S(P)); scFv Fragment | ELISA, FC | Mouse scFv |
| TAB-634LC-S(P) | Mouse Anti-IL25 Recombinant Antibody (TAB-634LC-S(P)); scFv Fragment | ELISA, FC | Mouse scFv |
| TAB-632LC-F(E) | Mouse Anti-IL25 Recombinant Antibody (TAB-632LC-F(E)); Fab Fragment | ELISA, FC | Mouse Fab |
| TAB-634LC-F(E) | Mouse Anti-IL25 Recombinant Antibody (TAB-634LC-F(E)); Fab Fragment | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635LC | Human Anti-IL25 Recombinant Antibody (TAB-635LC) | ELISA, FuncS | Humanized IgG4 |
| HPAB-M0541-YC | Mouse Anti-IL25 Recombinant Antibody (HPAB-M0541-YC) | Neut | Mouse IgG |
| HPAB-AP694-YC | Human Anti-IL25 Recombinant Antibody (HPAB-AP694-YC) | ELISA | Chimeric (mouse/human) IgG |
| HPAB-AP695-YC | Human Anti-IL25 Recombinant Antibody (HPAB-AP695-YC) | ELISA | Humanized (mouse/human) IgG |
| HPAB-AP696-YC | Human Anti-IL25 Recombinant Antibody (HPAB-AP696-YC) | ELISA, FuncS | Humanized (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635LC-F(E) | Human Anti-IL25 Recombinant Antibody; Fab Fragment (TAB-635LC-F(E)) | ELISA, Neut, FuncS | Humanized Fab |
| HPAB-0036-FY-F(E) | Mouse Anti-IL25 Recombinant Antibody; Fab Fragment (HPAB-0036-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-AP694-YC-F(E) | Human Anti-IL25 Recombinant Antibody; Fab Fragment (HPAB-AP694-YC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| HPAB-AP695-YC-F(E) | Human Anti-IL25 Recombinant Antibody; Fab Fragment (HPAB-AP695-YC-F(E)) | ELISA | Humanized (mouse/human) Fab |
| HPAB-AP696-YC-F(E) | Human Anti-IL25 Recombinant Antibody; Fab Fragment (HPAB-AP696-YC-F(E)) | ELISA, FuncS | Humanized (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1341CQ | Mouse Anti-Il25 Recombinant Antibody (clone CBL388) | Neut | Mouse IgG2b |
| NEUT-1342CQ | Rat Anti-Il25 Recombinant Antibody (NEUT-1342CQ) | ELISA, Neut | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1805 | Rabbit Anti-IL25 Recombinant Antibody (clone DS1805AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3517 | Anti-IL25 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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