Afuco™ Anti-IL5 ADCC Recombinant Antibody (Mepolizumab), ADCC Enhanced (CAT#: AFC-TAB-031)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL5. Mepolizumab (proposed trade name Bosatria) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5), and is used to treat certain kinds of asthma and white blood cell diseases. Recent studies have concluded that mepolizumab may improve exacerbations in patients with severe eosinophilic asthma, an adult-onset asthma which represents less than 5% of all asthma. IL-5 is a chemical messenger in the immune system that stimulates the growth of eosinophils. In eosinophilic asthma, eosinophils are present in the lungs. When mepolizumab was given to people with eosinophilic asthma, it eliminated eosinophils from the bloodstream,and reduced eosinophils in the lungs and bone marrow. Mepolizumab also reduced the number of asthma exacerbations, and reduced the need for corticosteroids.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Hep G2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113525-IL5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113525-IL5
Figure 1 RNA cell line category: Cell line enhanced (Hep G2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113525-IL5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113525-IL5
Specifications
- Immunogen
- Recombinant human IL5.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Mepolizumab
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Trade name
- Bosatria
- Generic Name
- Mepolizumab
- Related Disease
- Asthma
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Mepolizumab; bosatria; 196078-29-2; SB-240563; IL5; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; B cell differentiation factor I; EDF; eosinophil differentiation factor; IL 5; interleukin 5; T cell replacing factor; TRF; T-cell replacing factor
- Gene ID
- 3567
- UniProt ID
- P05113
Related Resources
Please refer to Mepolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Mepolizumab.
Asthma
Inflammatory Bowel Diseases
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Mepolizumab"
Anti-Human IL5 Recombinant Antibody (Mepolizumab)Recombinant monoclonal antibody to Human IL5. Mepolizumab (proposed trade name Bosatria) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5), and is used to treat certain kinds of asthma and white blood cell diseases. Recent studies have concluded that mepolizumab may improve exacerbations in patients with severe eosinophilic asthma, an adult-onset asthma which represents less than 5% of all asthma. IL-5 is a chemical messenger in the immune system that stimulates the growth of eosinophils. In eosinophilic asthma, eosinophils are present in the lungs. When mepolizumab was given to people with eosinophilic asthma, it eliminated eosinophils from the bloodstream,and reduced eosinophils in the lungs and bone marrow. Mepolizumab also reduced the number of asthma exacerbations, and reduced the need for corticosteroids.
See other products for "Clone Mepolizumab"
See other products for "IL5"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1202z | Mouse Anti-IL5 Recombinant Antibody (clone 37C3) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| HPAB-0001-CN | Human Anti-IL5 Recombinant Antibody (clone h39D10) | ELISA | Humanized IgG |
| HPAB-0875-FY | Human Anti-IL5 Recombinant Antibody (HPAB-0875-FY) | ELISA | Humanized IgG |
| HPAB-1617WJ | Mouse Anti-IL5 Recombinant Antibody (clone 2F2) | ELISA, WB, Neut | Mouse IgG |
| HPAB-1618WJ | Mouse Anti-IL5 Recombinant Antibody (clone 2E3) | ELISA, WB, Neut | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-031 | Anti-Human IL5 Recombinant Antibody (Mepolizumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
| TAB-136 | Anti-Human IL5 Recombinant Antibody (Reslizumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG4 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1437CQ | Mouse Anti-IL5 Recombinant Antibody (clone CBL632) | ELISA, Neut | Mouse IgG2a |
| NEUT-1438CQ | Mouse Anti-IL5 Recombinant Antibody (clone CBL420) | Neut | Mouse IgG1 |
| NEUT-1439CQ | Rat Anti-IL5 Recombinant Antibody (clone CBL900) | ELISA, FC, IF, Neut, WB | Rat IgG1, κ |
| NEUT-1440CQ | Rat Anti-IL5 Recombinant Antibody (clone JES1-39D10) | ELISA, ELISPOT, Neut, ICFC, IHC, WB | Rat IgG2a, κ |
| NEUT-1441CQ | Rat Anti-IL5 Recombinant Antibody (clone JES1-5A10) | ELISA, ELISPOT, Neut | Rat IgG2a, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1443CQ | Rat Anti-IL5 Recombinant Antibody (clone TRFK4) | ELISA, Inhib, WB | Rat IgG2a |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0001-CN-S(P) | Human Anti-IL5 Recombinant Antibody (clone h39D10); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0250CQ-S(P) | Human Anti-IL5 Recombinant Antibody; scFv Fragment (HPAB-0250CQ-S(P)) | ELISA, Neut, FuncS | Human scFv |
| HPAB-1249-FY-F(E) | Mouse Anti-IL5 Recombinant Antibody; Fab Fragment (HPAB-1249-FY-F(E)) | Neut | Mouse Fab |
| HPAB-1617WJ-S(P) | Mouse Anti-IL5 Recombinant Antibody; scFv Fragment (clone 2F2) | ELISA, WB, Neut | Mouse scFv |
| HPAB-1618WJ-S(P) | Mouse Anti-IL5 Recombinant Antibody; scFv Fragment (clone 2E3) | ELISA, WB, Neut | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0359-YC-F(E) | Human Anti-IL5 Recombinant Antibody; Fab Fragment (HPAB-N0359-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-0053-YJ-F(E) | Human Anti-IL5 Recombinant Antibody (clone CMX5-1); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0875-FY-S(P) | Human Anti-IL5 Recombinant Antibody; scFv Fragment (HPAB-0875-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-1617WJ-F(E) | Mouse Anti-IL5 Recombinant Antibody; Fab Fragment (clone 2F2) | ELISA, WB, Neut | Mouse Fab |
| HPAB-1618WJ-F(E) | Mouse Anti-IL5 Recombinant Antibody; Fab Fragment (clone 2E3) | ELISA, WB, Neut | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-136 | Afuco™ Anti-IL5 ADCC Recombinant Antibody (Reslizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AFC-TAB-031. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.